Comparison of selection pressures on the HA gene of pandemic (2009) and seasonal human and swine influenza A H1 subtype viruses

Yuki Furuse, Kozue Shimabukuro, Takashi Odagiri, Rumi Sawayama, Takashi Okada, Irona Khandaker, Akira Suzuki, Hitoshi Oshitani

研究成果: Article査読

33 被引用数 (Scopus)

抄録

The 2009 human pandemic influenza (H1N1) virus possesses the HA gene of the H1 subtype. The evolutionary process of the 2009 H1N1 virus remains to be defined. We performed genetic analyses of the HA gene by comparing the 2009 H1N1 virus with seasonal human and swine viruses.We analyzed sequences of 116 2009 H1N1 viruses, and obtained 1457 seasonal H1N1, 365 swine H1, and 1332 2009 H1N1 viruses from the database. Selection pressure for the 2009 H1N1 virus was higher than that for the swine virus and equivalent to that for the seasonal virus. Positions 206 and 264 were found to be positively selected sites. We also identified sites under different selection pressures from the seasonal or swine virus that may be involved in imparting significant biological characteristics.The evolutionary characteristics of the H1 gene of the 2009 H1N1 virus differed from those of seasonal and swine viruses.

本文言語English
ページ(範囲)314-321
ページ数8
ジャーナルVirology
405
2
DOI
出版ステータスPublished - 2010 9 30

ASJC Scopus subject areas

  • ウイルス学

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