Comparison of fatty acid profiles in the serum of patients with prostate cancer and benign prostatic hyperplasia

Yoon Jung Yang, Seon Hwa Lee, Sung Joon Hong, Bong Chul Chung

研究成果: Article査読

71 被引用数 (Scopus)

抄録

Objective: The role of dietary fatty acids (FAs) in benign and malignant prostatic diseases was investigated by comparing the composition value of serum fatty acids in the normal controls, and patients with prostate cancer (PC) and benign prostatic hyperplasia (BPH). Also, to estimate a possible association between PC risk and PUFAs, ω-3, ω-6 and ω-3/ω-6 FA composition ratios were compared among these groups. Methods: Serum samples were obtained from 24 BPH and 19 PC patients, and from 21 age-matched normal male subjects. The serum concentration of 21 fatty acids was determined using gas chromatography/mass spectrometry. Result: The proportional values of saturated fatty acids (SFAs) groups demonstrated no specific difference between the control subjects and the patients. In the polyunsaturated fatty acids (PUFAs), we found that the ω-3 PUFAs level was significantly decreased in patient with BPH and PC and that the ω-6 PUFAs level was increased in PC only. The ratio of ω-3/ω-6 PUFAs decreased in the following order of normal, BPH, and PC. Conclusion: It was proposed that the changed composition level of PUFAs including ω-3 and ω-6 PUFAs have certain relationship with both prostatic diseases. Therefore, the ratio of ω-3/ω-6 PUFAs also may have an important association with the benign and malignant status of prostatic disease.

本文言語English
ページ(範囲)405-409
ページ数5
ジャーナルClinical Biochemistry
32
6
DOI
出版ステータスPublished - 1999 8
外部発表はい

ASJC Scopus subject areas

  • 臨床生化学

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