Comparison between in vivo and in vitro pharmacokinetics of succinylcholine in humans

M. Kato, T. Shiratori, M. Yamamuro, S. Haga, K. Hoshi, S. Matsukawa, I. M. Jalal, Y. Hashimoto

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Purpose. To compare the in vivo and in vitro pharmacokinetics of succinylcholine (SCh) in humans. Methods. A bolus of SCh 1 mg · kg-1 (n = 7) or 2 mg · kg-1 (n = 11) was given to 18 patients anesthetized with thiopental. Arterial blood samples for determination of in vivo SCh concentrations were collected every 30 s for 5 min. Another 20-ml blood sample was obtained before induction of anesthesia for determination of in vitro SCh. Concentrations of SCh were measured by high-performance liquid chromatography. In vivo and in vitro concentrations of SCh vs time data were analyzed by the one-compartment model. Results. The respective in vivo and in vitro pharmacokinetic parameters (SCh 1 mg · kg-1 vs SCh 2 mg · kg-1) were as follows: Plasma clearance was 4.17 ± 2.37 and 1.85 ± 0.281 · min-1, P < 0.05, vs 2.91 ± 2.01 and 1.27 ± 0.431 · min-1, P < 0.05. Elimination half-life was 25.4 ± 10.6 and 47.4 ± 5.4 s, P < 0.002 vs 26.3 ± 10.0 and 75.2 ± 21.8 s, P < 0.00005. Conclusion. These results suggest that the rapid disappearance of SCh from the circulation is due to diffusion out of the blood vessels rather than to enzymatic hydrolysis.

本文言語English
ページ(範囲)189-192
ページ数4
ジャーナルJournal of Anesthesia
13
4
DOI
出版ステータスPublished - 1999

ASJC Scopus subject areas

  • 麻酔学および疼痛医療

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