Comparative test of the effctiveness of cefroxadine (cgp-9000) and cephalexin on acute respiratory tract infection by double blind method

Kenzo Shiota; Fumio Miki; Kbnji Kubo; Masakazu Kohno; Kenji Takamatsu; Yasumichi Kato; Akira Saito; Masumi Tomizawa; Ichiro Nakayama; Mikiya Sato; Morikuni Abe; Hiroyuki Tokunaka; Shuichi Yoshitani; Aiji Kojima; Takashi Sakuraba; Yoshio Kinoshita; Kiyofumi Ishikawa; Fumio Nagahama; Takahisa Saito; Kazuo Takebe; Mikihiko Kudo; Mitsuo Masuda; Ichiro Hirai; Hiroshi Saito; Kenichi Imamura; Yuzuru Fujioka; Tsuneharu Baba; Yoshihiro Kumasaka; Hisashi Nakahata; Kiyoshi Konno; Kohtaro Oizumi; Akira Watanabe; Masako Sasaki; Seiichi Aomuma; Kikuo Ohnuma; Shigeru Tamaki; Izumi Hayashi; Osamu Sekine; Fusanosuke Yamasaku; Yasutoshi Suzuki; Masataka Katsu; Masanori Adachi; Takashi Sohma; Keimei Mashimo; Sumio Yamaoka; Yasushi Ueda; Atsushi Saito; Jingoro Shimada; Keiichi Nakagawa; Masaru Koyama; Hideo Ikemoto; Kazuyoshi Watanabe; Takashi Mori; Akira Izumi; Junko Hibino; Hiroichi Tanimoto; Hiroyuki Kobayashi; Junzaburo Kabe; Mikihisa Suihara; Hiroyoshi Ishibashi; Otsuhjko Kunii; Kazufuto Fukaya; Ippei Fujimori; Toshio Sekimoto; Fuyuhiko Azuma; Michinori Kohno; Kohkichi Fukushima; Akira Ito; Kunihiko Shindo; Makio Kurihara; Ryuichiro Yamazaki; Toshiyuki Yamamoto; Masahito Kato; Hirohiko Nagasaka; Kohzo Mow; Saburo Kitaura; Kunio Nanjo; Jojchi Kato; Kaoru Ohyama; Kuniyasu Suzuki; Nobuo Maekawa; Michiyasu Nakanishi; Tsuneo Matsubara; Ryoichi Amita Yoshiro Oda; Fumiaki Uchihira; Hitoshi Nakai; Takehiro Tsujimoto; Iiroshi Okubo; Yuruko Okamoto; Yoshihiro Ueda; Fumihiko Uba; Keigo Maehara; Tooru Kurimura; Hideo Sasaki; Kazue Tamaki; Yusuke Morioka; Rinzo Soejima; Yoshihiko Tano; Yoshito Niki; Ejro Tsubura; Yoshiro Takishita; Katsuhito Kozai; Toshihiro Goto; Masahiko Nii; Masakazu Tamura; Yoshiro Sawae; Kohei Hara; Atsushi Saito; Masaru Nasu; Masao Nakatomi; Kinichi Izumikawa; Hisashi Ishikawa; Hiromaro Iwasaki; Kazuhiro Okuno; Masamoto Nakano; Akira Ikebe; Takeshi Ishizaki; Tsuneo Tsutsumi; Munrkazu Kiya; Takenori Matsumoto; Mitsunobu Akashi; Tohru Ishino; Rokushi Oka; Akimitsu Tomonaga; Toshio Fujioka; Yukio Imamura; Keizo Matsumoto; Kimitoshi Tamaki; Masashi Yamamoto; Haruhiko Tokuomi; Kiyoshi Shima; Yasutsugu Fukuda; Katsumasa Tokunaga; Kazuhiro Hamada; Kazuo Ishizaka; Yoshio Takaba; Yasumasa Hiro; Noritaka Tateishi; Ryuzo Kaku; Sadanobu Higuchi; Norihiko Nakahara; Tatsuo Tomita; Haruo Nozute

doi:10.11250/chemotherapy1953.28.918

Comparative test of the effctiveness of cefroxadine (cgp-9000) and cephalexin on acute respiratory tract infection by double blind method

Kenzo Shiota, Fumio Miki, Kbnji Kubo, Masakazu Kohno, Kenji Takamatsu, Yasumichi Kato, Akira Saito, Masumi Tomizawa, Ichiro Nakayama, Mikiya Sato, Morikuni Abe, Hiroyuki Tokunaka, Shuichi Yoshitani, Aiji Kojima, Takashi Sakuraba, Yoshio Kinoshita, Kiyofumi Ishikawa, Fumio Nagahama, Takahisa Saito, Kazuo TakebeMikihiko Kudo, Mitsuo Masuda, Ichiro Hirai, Hiroshi Saito, Kenichi Imamura, Yuzuru Fujioka, Tsuneharu Baba, Yoshihiro Kumasaka, Hisashi Nakahata, Kiyoshi Konno, Kohtaro Oizumi, Akira Watanabe, Masako Sasaki, Seiichi Aomuma, Kikuo Ohnuma, Shigeru Tamaki, Izumi Hayashi, Osamu Sekine, Fusanosuke Yamasaku, Yasutoshi Suzuki, Masataka Katsu, Masanori Adachi, Takashi Sohma, Keimei Mashimo, Sumio Yamaoka, Yasushi Ueda, Atsushi Saito, Jingoro Shimada, Keiichi Nakagawa, Masaru Koyama, Hideo Ikemoto, Kazuyoshi Watanabe, Takashi Mori, Akira Izumi, Junko Hibino, Hiroichi Tanimoto, Hiroyuki Kobayashi, Junzaburo Kabe, Mikihisa Suihara, Hiroyoshi Ishibashi, Otsuhjko Kunii, Kazufuto Fukaya, Ippei Fujimori, Toshio Sekimoto, Fuyuhiko Azuma, Michinori Kohno, Kohkichi Fukushima, Akira Ito, Kunihiko Shindo, Makio Kurihara, Ryuichiro Yamazaki, Toshiyuki Yamamoto, Masahito Kato, Hirohiko Nagasaka, Kohzo Mow, Saburo Kitaura, Kunio Nanjo, Jojchi Kato, Kaoru Ohyama, Kuniyasu Suzuki, Nobuo Maekawa, Michiyasu Nakanishi, Tsuneo Matsubara, Ryoichi Amita Yoshiro Oda, Fumiaki Uchihira, Hitoshi Nakai, Takehiro Tsujimoto, Iiroshi Okubo, Yuruko Okamoto, Yoshihiro Ueda, Fumihiko Uba, Keigo Maehara, Tooru Kurimura, Hideo Sasaki, Kazue Tamaki, Yusuke Morioka, Rinzo Soejima, Yoshihiko Tano, Yoshito Niki, Ejro Tsubura, Yoshiro Takishita, Katsuhito Kozai, Toshihiro Goto, Masahiko Nii, Masakazu Tamura, Yoshiro Sawae, Kohei Hara, Atsushi Saito, Masaru Nasu, Masao Nakatomi, Kinichi Izumikawa, Hisashi Ishikawa, Hiromaro Iwasaki, Kazuhiro Okuno, Masamoto Nakano, Akira Ikebe, Takeshi Ishizaki, Tsuneo Tsutsumi, Munrkazu Kiya, Takenori Matsumoto, Mitsunobu Akashi, Tohru Ishino, Rokushi Oka, Akimitsu Tomonaga, Toshio Fujioka, Yukio Imamura, Keizo Matsumoto, Kimitoshi Tamaki, Masashi Yamamoto, Haruhiko Tokuomi, Kiyoshi Shima, Yasutsugu Fukuda, Katsumasa Tokunaga, Kazuhiro Hamada, Kazuo Ishizaka, Yoshio Takaba, Yasumasa Hiro, Noritaka Tateishi, Ryuzo Kaku, Sadanobu Higuchi, Norihiko Nakahara, Tatsuo Tomita, Haruo Nozute

研究成果: Article › 査読

2 被引用数 (Scopus)

抄録

In order to compare the efficacy and side effect of cefroxadine with those of cephalexin on acute respiratory tract infection, cefroxadine at a daily dose of 750 mg (t. I. d.) and cephalexin at a daily dose of l,000mg (q.i. d.) were administered orally for 7 days in the treatment of acute pharyngitis, acute tonsillitis, and acute bronchitis, and a comparative double blind study on therapeutic effectiveness; side effect, and usefulness of both drugs was performed at 30 institutions. Total administered cases were 329 (163 cases on cefroxadine, 166 cases on cephalexin). Out of 329 cases, cases adopted by the committee members for assessment of effectiveness were 275 (134 cases on cefroxadine; 141 cases on cephalexin), and cases for evaluation of side effects numbered to 314 (154 cases on cefroxadine, 160 cases on cephalexin), and cases for assessment of effectiveness as well as of usefulness by physicians in charge totalled to 303 (147 cases on cefroxadine, 156 cases on cephalexin). The results obtained were as follows : 1. As to the therapeutic effect of cefroxadine (750 mg daily) and cephalexin (1,000 mg daily) in the treatment of acute respiratory tract infection, 63.5% in the cefroxadine group and 68.8% in the cephalexin group were rated as effective according to the assessment by the committee members and 68.0% in the cefroxadine group and 71.8% in the cephalexin group were rated effective according to the assessment by physicians in charge. No significant difference in any of them was noted between both groups. 2. Regarding the incidence of side effects, the number of the cases including the ones in which laboratory tests showed abnormal values was 22 cases (14.3%) in the cefroxadine group and 27 cases (16.9%) in the cephalexin group. There was no significant difference between both groups. 3 In respect to the usefulness of the drugs, in 90.5% of the cefroxadine group and 86.5% of the cephalexin group, each drug was regarded as “slightly useful” or more. No significant difference was noted between both groups.

本文言語	English
ページ（範囲）	918-963
ページ数	46
ジャーナル	Chemotherapy
巻	28
号	7
DOI	https://doi.org/10.11250/chemotherapy1953.28.918
出版ステータス	Published - 1980
外部発表	はい

ASJC Scopus subject areas

薬理学（医学）
感染症
薬理学
創薬
腫瘍学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

文献へのアクセス

10.11250/chemotherapy1953.28.918

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引用スタイル

Shiota, K., Miki, F., Kubo, K., Kohno, M., Takamatsu, K., Kato, Y., Saito, A., Tomizawa, M., Nakayama, I., Sato, M., Abe, M., Tokunaka, H., Yoshitani, S., Kojima, A., Sakuraba, T., Kinoshita, Y., Ishikawa, K., Nagahama, F., Saito, T., ... Nozute, H. (1980). Comparative test of the effctiveness of cefroxadine (cgp-9000) and cephalexin on acute respiratory tract infection by double blind method. Chemotherapy, 28(7), 918-963. https://doi.org/10.11250/chemotherapy1953.28.918

Shiota, K, Miki, F, Kubo, K, Kohno, M, Takamatsu, K, Kato, Y, Saito, A, Tomizawa, M, Nakayama, I, Sato, M, Abe, M, Tokunaka, H, Yoshitani, S, Kojima, A, Sakuraba, T, Kinoshita, Y, Ishikawa, K, Nagahama, F, Saito, T, Takebe, K, Kudo, M, Masuda, M, Hirai, I, Saito, H, Imamura, K, Fujioka, Y, Baba, T, Kumasaka, Y, Nakahata, H, Konno, K, Oizumi, K, Watanabe, A, Sasaki, M, Aomuma, S, Ohnuma, K, Tamaki, S, Hayashi, I, Sekine, O, Yamasaku, F, Suzuki, Y, Katsu, M, Adachi, M, Sohma, T, Mashimo, K, Yamaoka, S, Ueda, Y, Saito, A, Shimada, J, Nakagawa, K, Koyama, M, Ikemoto, H, Watanabe, K, Mori, T, Izumi, A, Hibino, J, Tanimoto, H, Kobayashi, H, Kabe, J, Suihara, M, Ishibashi, H, Kunii, O, Fukaya, K, Fujimori, I, Sekimoto, T, Azuma, F, Kohno, M, Fukushima, K, Ito, A, Shindo, K, Kurihara, M, Yamazaki, R, Yamamoto, T, Kato, M, Nagasaka, H, Mow, K, Kitaura, S, Nanjo, K, Kato, J, Ohyama, K, Suzuki, K, Maekawa, N, Nakanishi, M, Matsubara, T, Oda, RAY, Uchihira, F, Nakai, H, Tsujimoto, T, Okubo, I, Okamoto, Y, Ueda, Y, Uba, F, Maehara, K, Kurimura, T, Sasaki, H, Tamaki, K, Morioka, Y, Soejima, R, Tano, Y, Niki, Y, Tsubura, E, Takishita, Y, Kozai, K, Goto, T, Nii, M, Tamura, M, Sawae, Y, Hara, K, Saito, A, Nasu, M, Nakatomi, M, Izumikawa, K, Ishikawa, H, Iwasaki, H, Okuno, K, Nakano, M, Ikebe, A, Ishizaki, T, Tsutsumi, T, Kiya, M, Matsumoto, T, Akashi, M, Ishino, T, Oka, R, Tomonaga, A, Fujioka, T, Imamura, Y, Matsumoto, K, Tamaki, K, Yamamoto, M, Tokuomi, H, Shima, K, Fukuda, Y, Tokunaga, K, Hamada, K, Ishizaka, K, Takaba, Y, Hiro, Y, Tateishi, N, Kaku, R, Higuchi, S, Nakahara, N, Tomita, T & Nozute, H 1980, 'Comparative test of the effctiveness of cefroxadine (cgp-9000) and cephalexin on acute respiratory tract infection by double blind method', Chemotherapy, vol. 28, no. 7, pp. 918-963. https://doi.org/10.11250/chemotherapy1953.28.918

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title = "Comparative test of the effctiveness of cefroxadine (cgp-9000) and cephalexin on acute respiratory tract infection by double blind method",

abstract = "In order to compare the efficacy and side effect of cefroxadine with those of cephalexin on acute respiratory tract infection, cefroxadine at a daily dose of 750 mg (t. I. d.) and cephalexin at a daily dose of l,000mg (q.i. d.) were administered orally for 7 days in the treatment of acute pharyngitis, acute tonsillitis, and acute bronchitis, and a comparative double blind study on therapeutic effectiveness; side effect, and usefulness of both drugs was performed at 30 institutions. Total administered cases were 329 (163 cases on cefroxadine, 166 cases on cephalexin). Out of 329 cases, cases adopted by the committee members for assessment of effectiveness were 275 (134 cases on cefroxadine; 141 cases on cephalexin), and cases for evaluation of side effects numbered to 314 (154 cases on cefroxadine, 160 cases on cephalexin), and cases for assessment of effectiveness as well as of usefulness by physicians in charge totalled to 303 (147 cases on cefroxadine, 156 cases on cephalexin). The results obtained were as follows : 1. As to the therapeutic effect of cefroxadine (750 mg daily) and cephalexin (1,000 mg daily) in the treatment of acute respiratory tract infection, 63.5% in the cefroxadine group and 68.8% in the cephalexin group were rated as effective according to the assessment by the committee members and 68.0% in the cefroxadine group and 71.8% in the cephalexin group were rated effective according to the assessment by physicians in charge. No significant difference in any of them was noted between both groups. 2. Regarding the incidence of side effects, the number of the cases including the ones in which laboratory tests showed abnormal values was 22 cases (14.3%) in the cefroxadine group and 27 cases (16.9%) in the cephalexin group. There was no significant difference between both groups. 3 In respect to the usefulness of the drugs, in 90.5% of the cefroxadine group and 86.5% of the cephalexin group, each drug was regarded as “slightly useful” or more. No significant difference was noted between both groups.",

author = "Kenzo Shiota and Fumio Miki and Kbnji Kubo and Masakazu Kohno and Kenji Takamatsu and Yasumichi Kato and Akira Saito and Masumi Tomizawa and Ichiro Nakayama and Mikiya Sato and Morikuni Abe and Hiroyuki Tokunaka and Shuichi Yoshitani and Aiji Kojima and Takashi Sakuraba and Yoshio Kinoshita and Kiyofumi Ishikawa and Fumio Nagahama and Takahisa Saito and Kazuo Takebe and Mikihiko Kudo and Mitsuo Masuda and Ichiro Hirai and Hiroshi Saito and Kenichi Imamura and Yuzuru Fujioka and Tsuneharu Baba and Yoshihiro Kumasaka and Hisashi Nakahata and Kiyoshi Konno and Kohtaro Oizumi and Akira Watanabe and Masako Sasaki and Seiichi Aomuma and Kikuo Ohnuma and Shigeru Tamaki and Izumi Hayashi and Osamu Sekine and Fusanosuke Yamasaku and Yasutoshi Suzuki and Masataka Katsu and Masanori Adachi and Takashi Sohma and Keimei Mashimo and Sumio Yamaoka and Yasushi Ueda and Atsushi Saito and Jingoro Shimada and Keiichi Nakagawa and Masaru Koyama and Hideo Ikemoto and Kazuyoshi Watanabe and Takashi Mori and Akira Izumi and Junko Hibino and Hiroichi Tanimoto and Hiroyuki Kobayashi and Junzaburo Kabe and Mikihisa Suihara and Hiroyoshi Ishibashi and Otsuhjko Kunii and Kazufuto Fukaya and Ippei Fujimori and Toshio Sekimoto and Fuyuhiko Azuma and Michinori Kohno and Kohkichi Fukushima and Akira Ito and Kunihiko Shindo and Makio Kurihara and Ryuichiro Yamazaki and Toshiyuki Yamamoto and Masahito Kato and Hirohiko Nagasaka and Kohzo Mow and Saburo Kitaura and Kunio Nanjo and Jojchi Kato and Kaoru Ohyama and Kuniyasu Suzuki and Nobuo Maekawa and Michiyasu Nakanishi and Tsuneo Matsubara and Oda, {Ryoichi Amita Yoshiro} and Fumiaki Uchihira and Hitoshi Nakai and Takehiro Tsujimoto and Iiroshi Okubo and Yuruko Okamoto and Yoshihiro Ueda and Fumihiko Uba and Keigo Maehara and Tooru Kurimura and Hideo Sasaki and Kazue Tamaki and Yusuke Morioka and Rinzo Soejima and Yoshihiko Tano and Yoshito Niki and Ejro Tsubura and Yoshiro Takishita and Katsuhito Kozai and Toshihiro Goto and Masahiko Nii and Masakazu Tamura and Yoshiro Sawae and Kohei Hara and Atsushi Saito and Masaru Nasu and Masao Nakatomi and Kinichi Izumikawa and Hisashi Ishikawa and Hiromaro Iwasaki and Kazuhiro Okuno and Masamoto Nakano and Akira Ikebe and Takeshi Ishizaki and Tsuneo Tsutsumi and Munrkazu Kiya and Takenori Matsumoto and Mitsunobu Akashi and Tohru Ishino and Rokushi Oka and Akimitsu Tomonaga and Toshio Fujioka and Yukio Imamura and Keizo Matsumoto and Kimitoshi Tamaki and Masashi Yamamoto and Haruhiko Tokuomi and Kiyoshi Shima and Yasutsugu Fukuda and Katsumasa Tokunaga and Kazuhiro Hamada and Kazuo Ishizaka and Yoshio Takaba and Yasumasa Hiro and Noritaka Tateishi and Ryuzo Kaku and Sadanobu Higuchi and Norihiko Nakahara and Tatsuo Tomita and Haruo Nozute",

year = "1980",

doi = "10.11250/chemotherapy1953.28.918",

language = "English",

volume = "28",

pages = "918--963",

journal = "CHEMOTHERAPY",

issn = "0009-3165",

number = "7",

}

TY - JOUR

T1 - Comparative test of the effctiveness of cefroxadine (cgp-9000) and cephalexin on acute respiratory tract infection by double blind method

AU - Shiota, Kenzo

AU - Miki, Fumio

AU - Kubo, Kbnji

AU - Kohno, Masakazu

AU - Takamatsu, Kenji

AU - Kato, Yasumichi

AU - Saito, Akira

AU - Tomizawa, Masumi

AU - Nakayama, Ichiro

AU - Sato, Mikiya

AU - Abe, Morikuni

AU - Tokunaka, Hiroyuki

AU - Yoshitani, Shuichi

AU - Kojima, Aiji

AU - Sakuraba, Takashi

AU - Kinoshita, Yoshio

AU - Ishikawa, Kiyofumi

AU - Nagahama, Fumio

AU - Saito, Takahisa

AU - Takebe, Kazuo

AU - Kudo, Mikihiko

AU - Masuda, Mitsuo

AU - Hirai, Ichiro

AU - Saito, Hiroshi

AU - Imamura, Kenichi

AU - Fujioka, Yuzuru

AU - Baba, Tsuneharu

AU - Kumasaka, Yoshihiro

AU - Nakahata, Hisashi

AU - Konno, Kiyoshi

AU - Oizumi, Kohtaro

AU - Watanabe, Akira

AU - Sasaki, Masako

AU - Aomuma, Seiichi

AU - Ohnuma, Kikuo

AU - Tamaki, Shigeru

AU - Hayashi, Izumi

AU - Sekine, Osamu

AU - Yamasaku, Fusanosuke

AU - Suzuki, Yasutoshi

AU - Katsu, Masataka

AU - Adachi, Masanori

AU - Sohma, Takashi

AU - Mashimo, Keimei

AU - Yamaoka, Sumio

AU - Ueda, Yasushi

AU - Saito, Atsushi

AU - Shimada, Jingoro

AU - Nakagawa, Keiichi

AU - Koyama, Masaru

AU - Ikemoto, Hideo

AU - Watanabe, Kazuyoshi

AU - Mori, Takashi

AU - Izumi, Akira

AU - Hibino, Junko

AU - Tanimoto, Hiroichi

AU - Kobayashi, Hiroyuki

AU - Kabe, Junzaburo

AU - Suihara, Mikihisa

AU - Ishibashi, Hiroyoshi

AU - Kunii, Otsuhjko

AU - Fukaya, Kazufuto

AU - Fujimori, Ippei

AU - Sekimoto, Toshio

AU - Azuma, Fuyuhiko

AU - Kohno, Michinori

AU - Fukushima, Kohkichi

AU - Ito, Akira

AU - Shindo, Kunihiko

AU - Kurihara, Makio

AU - Yamazaki, Ryuichiro

AU - Yamamoto, Toshiyuki

AU - Kato, Masahito

AU - Nagasaka, Hirohiko

AU - Mow, Kohzo

AU - Kitaura, Saburo

AU - Nanjo, Kunio

AU - Kato, Jojchi

AU - Ohyama, Kaoru

AU - Suzuki, Kuniyasu

AU - Maekawa, Nobuo

AU - Nakanishi, Michiyasu

AU - Matsubara, Tsuneo

AU - Oda, Ryoichi Amita Yoshiro

AU - Uchihira, Fumiaki

AU - Nakai, Hitoshi

AU - Tsujimoto, Takehiro

AU - Okubo, Iiroshi

AU - Okamoto, Yuruko

AU - Ueda, Yoshihiro

AU - Uba, Fumihiko

AU - Maehara, Keigo

AU - Kurimura, Tooru

AU - Sasaki, Hideo

AU - Tamaki, Kazue

AU - Morioka, Yusuke

AU - Soejima, Rinzo

AU - Tano, Yoshihiko

AU - Niki, Yoshito

AU - Tsubura, Ejro

AU - Takishita, Yoshiro

AU - Kozai, Katsuhito

AU - Goto, Toshihiro

AU - Nii, Masahiko

AU - Tamura, Masakazu

AU - Sawae, Yoshiro

AU - Hara, Kohei

AU - Saito, Atsushi

AU - Nasu, Masaru

AU - Nakatomi, Masao

AU - Izumikawa, Kinichi

AU - Ishikawa, Hisashi

AU - Iwasaki, Hiromaro

AU - Okuno, Kazuhiro

AU - Nakano, Masamoto

AU - Ikebe, Akira

AU - Ishizaki, Takeshi

AU - Tsutsumi, Tsuneo

AU - Kiya, Munrkazu

AU - Matsumoto, Takenori

AU - Akashi, Mitsunobu

AU - Ishino, Tohru

AU - Oka, Rokushi

AU - Tomonaga, Akimitsu

AU - Fujioka, Toshio

AU - Imamura, Yukio

AU - Matsumoto, Keizo

AU - Tamaki, Kimitoshi

AU - Yamamoto, Masashi

AU - Tokuomi, Haruhiko

AU - Shima, Kiyoshi

AU - Fukuda, Yasutsugu

AU - Tokunaga, Katsumasa

AU - Hamada, Kazuhiro

AU - Ishizaka, Kazuo

AU - Takaba, Yoshio

AU - Hiro, Yasumasa

AU - Tateishi, Noritaka

AU - Kaku, Ryuzo

AU - Higuchi, Sadanobu

AU - Nakahara, Norihiko

AU - Tomita, Tatsuo

AU - Nozute, Haruo

PY - 1980

Y1 - 1980

N2 - In order to compare the efficacy and side effect of cefroxadine with those of cephalexin on acute respiratory tract infection, cefroxadine at a daily dose of 750 mg (t. I. d.) and cephalexin at a daily dose of l,000mg (q.i. d.) were administered orally for 7 days in the treatment of acute pharyngitis, acute tonsillitis, and acute bronchitis, and a comparative double blind study on therapeutic effectiveness; side effect, and usefulness of both drugs was performed at 30 institutions. Total administered cases were 329 (163 cases on cefroxadine, 166 cases on cephalexin). Out of 329 cases, cases adopted by the committee members for assessment of effectiveness were 275 (134 cases on cefroxadine; 141 cases on cephalexin), and cases for evaluation of side effects numbered to 314 (154 cases on cefroxadine, 160 cases on cephalexin), and cases for assessment of effectiveness as well as of usefulness by physicians in charge totalled to 303 (147 cases on cefroxadine, 156 cases on cephalexin). The results obtained were as follows : 1. As to the therapeutic effect of cefroxadine (750 mg daily) and cephalexin (1,000 mg daily) in the treatment of acute respiratory tract infection, 63.5% in the cefroxadine group and 68.8% in the cephalexin group were rated as effective according to the assessment by the committee members and 68.0% in the cefroxadine group and 71.8% in the cephalexin group were rated effective according to the assessment by physicians in charge. No significant difference in any of them was noted between both groups. 2. Regarding the incidence of side effects, the number of the cases including the ones in which laboratory tests showed abnormal values was 22 cases (14.3%) in the cefroxadine group and 27 cases (16.9%) in the cephalexin group. There was no significant difference between both groups. 3 In respect to the usefulness of the drugs, in 90.5% of the cefroxadine group and 86.5% of the cephalexin group, each drug was regarded as “slightly useful” or more. No significant difference was noted between both groups.

AB - In order to compare the efficacy and side effect of cefroxadine with those of cephalexin on acute respiratory tract infection, cefroxadine at a daily dose of 750 mg (t. I. d.) and cephalexin at a daily dose of l,000mg (q.i. d.) were administered orally for 7 days in the treatment of acute pharyngitis, acute tonsillitis, and acute bronchitis, and a comparative double blind study on therapeutic effectiveness; side effect, and usefulness of both drugs was performed at 30 institutions. Total administered cases were 329 (163 cases on cefroxadine, 166 cases on cephalexin). Out of 329 cases, cases adopted by the committee members for assessment of effectiveness were 275 (134 cases on cefroxadine; 141 cases on cephalexin), and cases for evaluation of side effects numbered to 314 (154 cases on cefroxadine, 160 cases on cephalexin), and cases for assessment of effectiveness as well as of usefulness by physicians in charge totalled to 303 (147 cases on cefroxadine, 156 cases on cephalexin). The results obtained were as follows : 1. As to the therapeutic effect of cefroxadine (750 mg daily) and cephalexin (1,000 mg daily) in the treatment of acute respiratory tract infection, 63.5% in the cefroxadine group and 68.8% in the cephalexin group were rated as effective according to the assessment by the committee members and 68.0% in the cefroxadine group and 71.8% in the cephalexin group were rated effective according to the assessment by physicians in charge. No significant difference in any of them was noted between both groups. 2. Regarding the incidence of side effects, the number of the cases including the ones in which laboratory tests showed abnormal values was 22 cases (14.3%) in the cefroxadine group and 27 cases (16.9%) in the cephalexin group. There was no significant difference between both groups. 3 In respect to the usefulness of the drugs, in 90.5% of the cefroxadine group and 86.5% of the cephalexin group, each drug was regarded as “slightly useful” or more. No significant difference was noted between both groups.

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UR - http://www.scopus.com/inward/citedby.url?scp=0019124639&partnerID=8YFLogxK

U2 - 10.11250/chemotherapy1953.28.918

DO - 10.11250/chemotherapy1953.28.918

M3 - Article

AN - SCOPUS:0019124639

VL - 28

SP - 918

EP - 963

JO - CHEMOTHERAPY

JF - CHEMOTHERAPY

SN - 0009-3165

IS - 7

ER -