Comparative study on the effectiveness of bacampicillin and amoxicillin on pneumonia by double blind method

Kenzo Shiota; Fumio Miki; Tomokazu Asai; Kenji Kubo; Masakazu Kono; Kenji Takamatsu; Yasumichi Kato; Akira Saito; Ichiro Nakayama; Masumi Tomizawa; Tatsunori Shimizu; Fumio Nagahama; Tetsushi Koroku; Shinya Yasuda; Takashi Mikami; Norimichi Konno; Yasumasa Yokota; Masahiro Tsuji; Kazunori Harada; Seiji Abe; Kazuo Takebe; Kenichi Imamura; Muneki Sakakura; Masayoshi Kobayashi; Kenichi Kimura; Shuichiro Yoshida; Ichiro Hirai; Shiro Kosaka; Mitsuaki Yoshioka; Hitoshi Takishima; Sumio Arai; Kiyoshi Konno; Kotaro Oizumi; Akira Watanabe; Seiichi Aonuma; Hajimu Takeda; Shiro Kawashima; Osamu Sekine; Yoshimaru Usuda; Nobuki Aoki; Yutaka Kanazawa; Masataka Katsu; Shinji Okui; Hisashi Takizuka; Ryoichi Muraki; Keimei Mashimo; Otohiko Kunii; Kazufuto Fukaya; Keiichi Nakagawa; Kentaro Watanabe; Tatsuo Suzuki; Masaru Koyama; Norio Kihara; Kaoru Shimada; Katsumi Nakazawa; Kyoko Kazima; Yasushi Ueda; Osamu Kitamoto; Hiroyuki Kobayashi; Junzaburo Kabe; Ippei Fujimori; Toshio Sekimoto; Fuyuhiko Higashi; Toshiyuki Yamamoto; Masahito Kato; Saburo Kitaura; Yukio Goto; Masaru Onuma; Kaoru Oyama; Michiko Kanaki; Nobuo Maekawa; Michiyasu Nakanishi; Hiroshi Okubo; Yuruko Okamoto; Fumihiko Uba; Yoshihiro Ueda; Keigo Maehara; Takehiro Tsujimoto; Kenichi Shimizu; Hiroshi Maruyama; Natsuo Nishizawa; Tadayuki Terada; Rinzo Soejima; Yoshihiko Tano; Kenichi Shigeji; Yoshito Niki; Osamu Kurimura; Naomi Kimura; Eiro Tsubura; Toshihiro Goto; Katsuhito Kozai; Yoshihiro Takishita; Masakazu Tamura; Takuki Hashimoto; Seizaburo Taoka; Yoshihiro Sawae; Tsuneo Ishibashi; Masahiro Takamoto; Nobuyoshi Miyazaki; Kohei Hara; Masaru Nasu; Tsuneo Tsutsumi; Masao Nakatomi; Kinichi Izumikawa; Keizo Matsumoto; Hiroshi Suzuki; Harumi Shishido; Kimitoshi Tamaki

doi:10.11250/chemotherapy1953.27.725

Comparative study on the effectiveness of bacampicillin and amoxicillin on pneumonia by double blind method

Kenzo Shiota, Fumio Miki, Tomokazu Asai, Kenji Kubo, Masakazu Kono, Kenji Takamatsu, Yasumichi Kato, Akira Saito, Ichiro Nakayama, Masumi Tomizawa, Tatsunori Shimizu, Fumio Nagahama, Tetsushi Koroku, Shinya Yasuda, Takashi Mikami, Norimichi Konno, Yasumasa Yokota, Masahiro Tsuji, Kazunori Harada, Seiji AbeKazuo Takebe, Kenichi Imamura, Muneki Sakakura, Masayoshi Kobayashi, Kenichi Kimura, Shuichiro Yoshida, Ichiro Hirai, Shiro Kosaka, Mitsuaki Yoshioka, Hitoshi Takishima, Sumio Arai, Kiyoshi Konno, Kotaro Oizumi, Akira Watanabe, Seiichi Aonuma, Hajimu Takeda, Shiro Kawashima, Osamu Sekine, Yoshimaru Usuda, Nobuki Aoki, Yutaka Kanazawa, Masataka Katsu, Shinji Okui, Hisashi Takizuka, Ryoichi Muraki, Keimei Mashimo, Otohiko Kunii, Kazufuto Fukaya, Keiichi Nakagawa, Kentaro Watanabe, Tatsuo Suzuki, Masaru Koyama, Norio Kihara, Kaoru Shimada, Katsumi Nakazawa, Kyoko Kazima, Yasushi Ueda, Osamu Kitamoto, Hiroyuki Kobayashi, Junzaburo Kabe, Ippei Fujimori, Toshio Sekimoto, Fuyuhiko Higashi, Toshiyuki Yamamoto, Masahito Kato, Saburo Kitaura, Yukio Goto, Masaru Onuma, Kaoru Oyama, Michiko Kanaki, Nobuo Maekawa, Michiyasu Nakanishi, Hiroshi Okubo, Yuruko Okamoto, Fumihiko Uba, Yoshihiro Ueda, Keigo Maehara, Takehiro Tsujimoto, Kenichi Shimizu, Hiroshi Maruyama, Natsuo Nishizawa, Tadayuki Terada, Rinzo Soejima, Yoshihiko Tano, Kenichi Shigeji, Yoshito Niki, Osamu Kurimura, Naomi Kimura, Eiro Tsubura, Toshihiro Goto, Katsuhito Kozai, Yoshihiro Takishita, Masakazu Tamura, Takuki Hashimoto, Seizaburo Taoka, Yoshihiro Sawae, Tsuneo Ishibashi, Masahiro Takamoto, Nobuyoshi Miyazaki, Kohei Hara, Masaru Nasu, Tsuneo Tsutsumi, Masao Nakatomi, Kinichi Izumikawa, Keizo Matsumoto, Hiroshi Suzuki, Harumi Shishido, Kimitoshi Tamaki

研究成果: Article › 査読

3 被引用数 (Scopus)

抄録

In order to compare the efficacy and side effects of Bacampicillin (BAPC) with those of Amoxicillin (AMPC), a comparative clincal trial has been carried out upon pneumonia at 35 institutions all over the country by means of a double-blind method. BAPC and AMPC were orally administered to 153 patients with pneumonia at a daily dose of 1g for 14 days. A statistical analysis between the two drugs was made on the efficacy in 116 cases excluding the cases which deviated rules of the protocol and on side effects in 147 cases excluding the cases which deviated rules of the protocol. Furthermore, a statistical analysis between the two drugs was also made on the efficacy, side effects, and utility in almost all cases according to the judgement by doctors in charge. The results are as follows: 1. The clinical efficacy of BAPC at the daily dose of 1g was equal to that of AMPC in the treatment of pneumonia. 2. Regarding the degree of improvement of symptoms and laboratory test data, no significant difference was observed between the two groups except for the superiority of AMPC over BAPC in tne degree of improvement in CRP at the end of treatment. 3. No significant difference was observed between both groups in the occurrence of side effects.

本文言語	English
ページ（範囲）	725-759
ページ数	35
ジャーナル	Chemotherapy
巻	27
号	5
DOI	https://doi.org/10.11250/chemotherapy1953.27.725
出版ステータス	Published - 1979
外部発表	はい

ASJC Scopus subject areas

薬理学（医学）
感染症
薬理学
創薬
腫瘍学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

文献へのアクセス

10.11250/chemotherapy1953.27.725

他のファイルとリンク

引用スタイル

Shiota, K., Miki, F., Asai, T., Kubo, K., Kono, M., Takamatsu, K., Kato, Y., Saito, A., Nakayama, I., Tomizawa, M., Shimizu, T., Nagahama, F., Koroku, T., Yasuda, S., Mikami, T., Konno, N., Yokota, Y., Tsuji, M., Harada, K., ... Tamaki, K. (1979). Comparative study on the effectiveness of bacampicillin and amoxicillin on pneumonia by double blind method. Chemotherapy, 27(5), 725-759. https://doi.org/10.11250/chemotherapy1953.27.725

Shiota, K, Miki, F, Asai, T, Kubo, K, Kono, M, Takamatsu, K, Kato, Y, Saito, A, Nakayama, I, Tomizawa, M, Shimizu, T, Nagahama, F, Koroku, T, Yasuda, S, Mikami, T, Konno, N, Yokota, Y, Tsuji, M, Harada, K, Abe, S, Takebe, K, Imamura, K, Sakakura, M, Kobayashi, M, Kimura, K, Yoshida, S, Hirai, I, Kosaka, S, Yoshioka, M, Takishima, H, Arai, S, Konno, K, Oizumi, K, Watanabe, A, Aonuma, S, Takeda, H, Kawashima, S, Sekine, O, Usuda, Y, Aoki, N, Kanazawa, Y, Katsu, M, Okui, S, Takizuka, H, Muraki, R, Mashimo, K, Kunii, O, Fukaya, K, Nakagawa, K, Watanabe, K, Suzuki, T, Koyama, M, Kihara, N, Shimada, K, Nakazawa, K, Kazima, K, Ueda, Y, Kitamoto, O, Kobayashi, H, Kabe, J, Fujimori, I, Sekimoto, T, Higashi, F, Yamamoto, T, Kato, M, Kitaura, S, Goto, Y, Onuma, M, Oyama, K, Kanaki, M, Maekawa, N, Nakanishi, M, Okubo, H, Okamoto, Y, Uba, F, Ueda, Y, Maehara, K, Tsujimoto, T, Shimizu, K, Maruyama, H, Nishizawa, N, Terada, T, Soejima, R, Tano, Y, Shigeji, K, Niki, Y, Kurimura, O, Kimura, N, Tsubura, E, Goto, T, Kozai, K, Takishita, Y, Tamura, M, Hashimoto, T, Taoka, S, Sawae, Y, Ishibashi, T, Takamoto, M, Miyazaki, N, Hara, K, Nasu, M, Tsutsumi, T, Nakatomi, M, Izumikawa, K, Matsumoto, K, Suzuki, H, Shishido, H & Tamaki, K 1979, 'Comparative study on the effectiveness of bacampicillin and amoxicillin on pneumonia by double blind method', Chemotherapy, vol. 27, no. 5, pp. 725-759. https://doi.org/10.11250/chemotherapy1953.27.725

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abstract = "In order to compare the efficacy and side effects of Bacampicillin (BAPC) with those of Amoxicillin (AMPC), a comparative clincal trial has been carried out upon pneumonia at 35 institutions all over the country by means of a double-blind method. BAPC and AMPC were orally administered to 153 patients with pneumonia at a daily dose of 1g for 14 days. A statistical analysis between the two drugs was made on the efficacy in 116 cases excluding the cases which deviated rules of the protocol and on side effects in 147 cases excluding the cases which deviated rules of the protocol. Furthermore, a statistical analysis between the two drugs was also made on the efficacy, side effects, and utility in almost all cases according to the judgement by doctors in charge. The results are as follows: 1. The clinical efficacy of BAPC at the daily dose of 1g was equal to that of AMPC in the treatment of pneumonia. 2. Regarding the degree of improvement of symptoms and laboratory test data, no significant difference was observed between the two groups except for the superiority of AMPC over BAPC in tne degree of improvement in CRP at the end of treatment. 3. No significant difference was observed between both groups in the occurrence of side effects.",

author = "Kenzo Shiota and Fumio Miki and Tomokazu Asai and Kenji Kubo and Masakazu Kono and Kenji Takamatsu and Yasumichi Kato and Akira Saito and Ichiro Nakayama and Masumi Tomizawa and Tatsunori Shimizu and Fumio Nagahama and Tetsushi Koroku and Shinya Yasuda and Takashi Mikami and Norimichi Konno and Yasumasa Yokota and Masahiro Tsuji and Kazunori Harada and Seiji Abe and Kazuo Takebe and Kenichi Imamura and Muneki Sakakura and Masayoshi Kobayashi and Kenichi Kimura and Shuichiro Yoshida and Ichiro Hirai and Shiro Kosaka and Mitsuaki Yoshioka and Hitoshi Takishima and Sumio Arai and Kiyoshi Konno and Kotaro Oizumi and Akira Watanabe and Seiichi Aonuma and Hajimu Takeda and Shiro Kawashima and Osamu Sekine and Yoshimaru Usuda and Nobuki Aoki and Yutaka Kanazawa and Masataka Katsu and Shinji Okui and Hisashi Takizuka and Ryoichi Muraki and Keimei Mashimo and Otohiko Kunii and Kazufuto Fukaya and Keiichi Nakagawa and Kentaro Watanabe and Tatsuo Suzuki and Masaru Koyama and Norio Kihara and Kaoru Shimada and Katsumi Nakazawa and Kyoko Kazima and Yasushi Ueda and Osamu Kitamoto and Hiroyuki Kobayashi and Junzaburo Kabe and Ippei Fujimori and Toshio Sekimoto and Fuyuhiko Higashi and Toshiyuki Yamamoto and Masahito Kato and Saburo Kitaura and Yukio Goto and Masaru Onuma and Kaoru Oyama and Michiko Kanaki and Nobuo Maekawa and Michiyasu Nakanishi and Hiroshi Okubo and Yuruko Okamoto and Fumihiko Uba and Yoshihiro Ueda and Keigo Maehara and Takehiro Tsujimoto and Kenichi Shimizu and Hiroshi Maruyama and Natsuo Nishizawa and Tadayuki Terada and Rinzo Soejima and Yoshihiko Tano and Kenichi Shigeji and Yoshito Niki and Osamu Kurimura and Naomi Kimura and Eiro Tsubura and Toshihiro Goto and Katsuhito Kozai and Yoshihiro Takishita and Masakazu Tamura and Takuki Hashimoto and Seizaburo Taoka and Yoshihiro Sawae and Tsuneo Ishibashi and Masahiro Takamoto and Nobuyoshi Miyazaki and Kohei Hara and Masaru Nasu and Tsuneo Tsutsumi and Masao Nakatomi and Kinichi Izumikawa and Keizo Matsumoto and Hiroshi Suzuki and Harumi Shishido and Kimitoshi Tamaki",

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doi = "10.11250/chemotherapy1953.27.725",

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T1 - Comparative study on the effectiveness of bacampicillin and amoxicillin on pneumonia by double blind method

AU - Shiota, Kenzo

AU - Miki, Fumio

AU - Asai, Tomokazu

AU - Kubo, Kenji

AU - Kono, Masakazu

AU - Takamatsu, Kenji

AU - Kato, Yasumichi

AU - Saito, Akira

AU - Nakayama, Ichiro

AU - Tomizawa, Masumi

AU - Shimizu, Tatsunori

AU - Nagahama, Fumio

AU - Koroku, Tetsushi

AU - Yasuda, Shinya

AU - Mikami, Takashi

AU - Konno, Norimichi

AU - Yokota, Yasumasa

AU - Tsuji, Masahiro

AU - Harada, Kazunori

AU - Abe, Seiji

AU - Takebe, Kazuo

AU - Imamura, Kenichi

AU - Sakakura, Muneki

AU - Kobayashi, Masayoshi

AU - Kimura, Kenichi

AU - Yoshida, Shuichiro

AU - Hirai, Ichiro

AU - Kosaka, Shiro

AU - Yoshioka, Mitsuaki

AU - Takishima, Hitoshi

AU - Arai, Sumio

AU - Konno, Kiyoshi

AU - Oizumi, Kotaro

AU - Watanabe, Akira

AU - Aonuma, Seiichi

AU - Takeda, Hajimu

AU - Kawashima, Shiro

AU - Sekine, Osamu

AU - Usuda, Yoshimaru

AU - Aoki, Nobuki

AU - Kanazawa, Yutaka

AU - Katsu, Masataka

AU - Okui, Shinji

AU - Takizuka, Hisashi

AU - Muraki, Ryoichi

AU - Mashimo, Keimei

AU - Kunii, Otohiko

AU - Fukaya, Kazufuto

AU - Nakagawa, Keiichi

AU - Watanabe, Kentaro

AU - Suzuki, Tatsuo

AU - Koyama, Masaru

AU - Kihara, Norio

AU - Shimada, Kaoru

AU - Nakazawa, Katsumi

AU - Kazima, Kyoko

AU - Ueda, Yasushi

AU - Kitamoto, Osamu

AU - Kobayashi, Hiroyuki

AU - Kabe, Junzaburo

AU - Fujimori, Ippei

AU - Sekimoto, Toshio

AU - Higashi, Fuyuhiko

AU - Yamamoto, Toshiyuki

AU - Kato, Masahito

AU - Kitaura, Saburo

AU - Goto, Yukio

AU - Onuma, Masaru

AU - Oyama, Kaoru

AU - Kanaki, Michiko

AU - Maekawa, Nobuo

AU - Nakanishi, Michiyasu

AU - Okubo, Hiroshi

AU - Okamoto, Yuruko

AU - Uba, Fumihiko

AU - Ueda, Yoshihiro

AU - Maehara, Keigo

AU - Tsujimoto, Takehiro

AU - Shimizu, Kenichi

AU - Maruyama, Hiroshi

AU - Nishizawa, Natsuo

AU - Terada, Tadayuki

AU - Soejima, Rinzo

AU - Tano, Yoshihiko

AU - Shigeji, Kenichi

AU - Niki, Yoshito

AU - Kurimura, Osamu

AU - Kimura, Naomi

AU - Tsubura, Eiro

AU - Goto, Toshihiro

AU - Kozai, Katsuhito

AU - Takishita, Yoshihiro

AU - Tamura, Masakazu

AU - Hashimoto, Takuki

AU - Taoka, Seizaburo

AU - Sawae, Yoshihiro

AU - Ishibashi, Tsuneo

AU - Takamoto, Masahiro

AU - Miyazaki, Nobuyoshi

AU - Hara, Kohei

AU - Nasu, Masaru

AU - Tsutsumi, Tsuneo

AU - Nakatomi, Masao

AU - Izumikawa, Kinichi

AU - Matsumoto, Keizo

AU - Suzuki, Hiroshi

AU - Shishido, Harumi

AU - Tamaki, Kimitoshi

PY - 1979

Y1 - 1979

N2 - In order to compare the efficacy and side effects of Bacampicillin (BAPC) with those of Amoxicillin (AMPC), a comparative clincal trial has been carried out upon pneumonia at 35 institutions all over the country by means of a double-blind method. BAPC and AMPC were orally administered to 153 patients with pneumonia at a daily dose of 1g for 14 days. A statistical analysis between the two drugs was made on the efficacy in 116 cases excluding the cases which deviated rules of the protocol and on side effects in 147 cases excluding the cases which deviated rules of the protocol. Furthermore, a statistical analysis between the two drugs was also made on the efficacy, side effects, and utility in almost all cases according to the judgement by doctors in charge. The results are as follows: 1. The clinical efficacy of BAPC at the daily dose of 1g was equal to that of AMPC in the treatment of pneumonia. 2. Regarding the degree of improvement of symptoms and laboratory test data, no significant difference was observed between the two groups except for the superiority of AMPC over BAPC in tne degree of improvement in CRP at the end of treatment. 3. No significant difference was observed between both groups in the occurrence of side effects.

AB - In order to compare the efficacy and side effects of Bacampicillin (BAPC) with those of Amoxicillin (AMPC), a comparative clincal trial has been carried out upon pneumonia at 35 institutions all over the country by means of a double-blind method. BAPC and AMPC were orally administered to 153 patients with pneumonia at a daily dose of 1g for 14 days. A statistical analysis between the two drugs was made on the efficacy in 116 cases excluding the cases which deviated rules of the protocol and on side effects in 147 cases excluding the cases which deviated rules of the protocol. Furthermore, a statistical analysis between the two drugs was also made on the efficacy, side effects, and utility in almost all cases according to the judgement by doctors in charge. The results are as follows: 1. The clinical efficacy of BAPC at the daily dose of 1g was equal to that of AMPC in the treatment of pneumonia. 2. Regarding the degree of improvement of symptoms and laboratory test data, no significant difference was observed between the two groups except for the superiority of AMPC over BAPC in tne degree of improvement in CRP at the end of treatment. 3. No significant difference was observed between both groups in the occurrence of side effects.

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Comparative study on the effectiveness of bacampicillin and amoxicillin on pneumonia by double blind method

抄録

ASJC Scopus subject areas

UN SDG

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