In order to compare the efficacy and side effects of Bacampicillin (BAPC) with those of Amoxicillin (AMPC), a comparative clincal trial has been carried out upon pneumonia at 35 institutions all over the country by means of a double-blind method. BAPC and AMPC were orally administered to 153 patients with pneumonia at a daily dose of 1g for 14 days. A statistical analysis between the two drugs was made on the efficacy in 116 cases excluding the cases which deviated rules of the protocol and on side effects in 147 cases excluding the cases which deviated rules of the protocol. Furthermore, a statistical analysis between the two drugs was also made on the efficacy, side effects, and utility in almost all cases according to the judgement by doctors in charge. The results are as follows: 1. The clinical efficacy of BAPC at the daily dose of 1g was equal to that of AMPC in the treatment of pneumonia. 2. Regarding the degree of improvement of symptoms and laboratory test data, no significant difference was observed between the two groups except for the superiority of AMPC over BAPC in tne degree of improvement in CRP at the end of treatment. 3. No significant difference was observed between both groups in the occurrence of side effects.
|出版ステータス||Published - 1979|
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