Comparative Studies on the Effectiveness of T-1982 and That of Cefmetazole in Respiratory Tract Infections

Ippei Fujimori; Yoshio Kobayashi; Koujiro Sekita; Yasumichi Kato; Akira Saito; Kiyofumi Ishikawa; Masumi Tomizawa; Ichiro Nakayama; Fumio Nagahama; Sokichi Onodera; Eiichi Sakai; Takehito Nakabayashi; Tetsuji Koroku; Takahisa Saito; Akihiko Kuze; Osamu Mitsuhashi; Mitsuko Yasuda; Satoshi Yaguchi; Hiroshi Kon; Nobuo Watanabe; Jutaro Shimomura; Yuichi Sasaki; Shinichi Oshima; Kazuo Takebe; Osamu Uehara; Kazuo Sasaki; Hiroyasu Kawabe; Toyokazu Tamura; Kenichi Kimura; Tsuneharu Baba; Aiichiro Kurihara; Naoyoshi Masaki; Shiro Kosaka; Tamotsu Takishima; Kazuki Konishi; Masahiro Sakamoto; Kiyoshi Konno; Kotaro Oizumi; Akira Watanabe; Izumi Hayashi; Hajime Takeda; Fusanosuke Yamasaku; Yasutoshi Suzuki; Osamu Serine; Yoshimaru Usuda; Nobuki Aoki; Masataka Katsu; Shinji Okui; Hisashi Takizuka; Koji Ogiwara; Teruo Aoyagi; Sadatomo Watanabe; Yasushi Ueda; Atsushi Saito; Takehisa Yamaji; Tadashi Miyahara; Hideo Ikemoto; Kazuyoshi Watanabe; Hiroyuki Kobayashi; Hiroaki Takeda; Noriko Kawamata; Keiichi Nakagawa; Akira Fukui; Yoshiaki Kawaguchi; Masaru Koyama; Takashi Yamamoto; Kougin Kin; Ryuji Akiyoshi; Hiroichi Tanimoto; Koichiro Nakada; Akio Tachibana; Yoshitaka Nakamori; Naohiko Chonabayashi; Kaoru Shimada; Takashi Inamatsu; Keimei Mashimo; Sumio Yamaoka; Junzaburo Kabe; Yoshihiro Ishibashi; Kazufuto Fukaya; Fuyuhiko Higashi; Kenji Mitsui; Kohkichi Fukushima; Akira Ito; Kunihiko Shindo; Motonori Fukumura; Hiroshi Sakamoto; Shigeki Odagiri; Hideyuki Hasegawa; Makio Kurihara; Tadashi Takigami; Kaoru Oyama; Ryusaku Shimizu; Nobuo Oya; Mitsuru Hayase; Kaoru Shimokata; Masanori Morise; Osamu Kohnou; Masahiko Yamamoto; Takahiko Sugiura; Yoshio Torii; Mitsuru Iwakura; Keisuke Nishiwaki; Shuzo Sakai; Yoshihiro Senda; Yasuo Nomura; Yasutaka Ina; Manabu Asai; Mikiko Morita; Susumu Suetsugu; Saiji Yoshii; Masahito Kato; Kunio Nanjo; Joichi Kato; Saburo Kitaura; Kazuo Yoshitomo; Motoko Yamamoto; Masako Takizawa; Akihiko Kishimoto; Toshihiko Takeuchi; Toshiyuki Yamamoto; Kanzo Suzuki; Nobuo Maekawa; Michiyasu Nakanishi; Fumio Ito; Masayasu Yamazaki; Einosuke Ueda; Joichi Konishiike; Yoshinobu Konnai; Hisao Takahashi; Tadao Ochi; Shigenori Nakajima; Ohmi Takagi; Toru Niinaka; Yoshitaka Yamamoto; Kojiro Kondo; Fumio Miki; Fumio Miki; Hiroshi Okubo; Yuruko Okamoto; Keigo Maehara; Rinzo Soejima; Yoshihito Niki; Masayoshi Kawanishi; Eiro Tsubura; Toshihiro Goto; Yoshihiro Takishita; Yuji Higuchi; Yoshiro Sawae; Kaoru Okada; Toshiyuki Yanase; Nobuaki Shigematsu; Kazuyuki Higuchi; Nobuyoshi Miyazaki; Kohei Hara; Atsushi Saito; Keizo Yamaguchi; Yoji Suzuyama; Yoshiteru Shigeno; Hikaru Tanaka; Keizo Matsumoto; Yoshio Uzuka; Masato Hayashi; Hisao Kimura; Mineharu Sugimoto; Masayuki Ando; Hitoshi Nagano; Hiroharu Kondo; Kohji Mochizuki; Eriko Shigetoh; Reiko Nagao; Kenichi Matsuba; Atsushi Shinoda; Yoshiya Kitahara; Yosuke Egashira; Etsuo Kinuwaki; Kiyoshi Shima; Yoichi Hokamura; Toshiaki Yasutake; Yoshinobu Honda; Nozomu Kosakai; Jun Igari; Toyoko Oguri

doi:10.11250/chemotherapy1953.31.528

Comparative Studies on the Effectiveness of T-1982 and That of Cefmetazole in Respiratory Tract Infections

Ippei Fujimori, Yoshio Kobayashi, Koujiro Sekita, Yasumichi Kato, Akira Saito, Kiyofumi Ishikawa, Masumi Tomizawa, Ichiro Nakayama, Fumio Nagahama, Sokichi Onodera, Eiichi Sakai, Takehito Nakabayashi, Tetsuji Koroku, Takahisa Saito, Akihiko Kuze, Osamu Mitsuhashi, Mitsuko Yasuda, Satoshi Yaguchi, Hiroshi Kon, Nobuo WatanabeJutaro Shimomura, Yuichi Sasaki, Shinichi Oshima, Kazuo Takebe, Osamu Uehara, Kazuo Sasaki, Hiroyasu Kawabe, Toyokazu Tamura, Kenichi Kimura, Tsuneharu Baba, Aiichiro Kurihara, Naoyoshi Masaki, Shiro Kosaka, Tamotsu Takishima, Kazuki Konishi, Masahiro Sakamoto, Kiyoshi Konno, Kotaro Oizumi, Akira Watanabe, Izumi Hayashi, Hajime Takeda, Fusanosuke Yamasaku, Yasutoshi Suzuki, Osamu Serine, Yoshimaru Usuda, Nobuki Aoki, Masataka Katsu, Shinji Okui, Hisashi Takizuka, Koji Ogiwara, Teruo Aoyagi, Sadatomo Watanabe, Yasushi Ueda, Atsushi Saito, Takehisa Yamaji, Tadashi Miyahara, Hideo Ikemoto, Kazuyoshi Watanabe, Hiroyuki Kobayashi, Hiroaki Takeda, Noriko Kawamata, Keiichi Nakagawa, Akira Fukui, Yoshiaki Kawaguchi, Masaru Koyama, Takashi Yamamoto, Kougin Kin, Ryuji Akiyoshi, Hiroichi Tanimoto, Koichiro Nakada, Akio Tachibana, Yoshitaka Nakamori, Naohiko Chonabayashi, Kaoru Shimada, Takashi Inamatsu, Keimei Mashimo, Sumio Yamaoka, Junzaburo Kabe, Yoshihiro Ishibashi, Kazufuto Fukaya, Fuyuhiko Higashi, Kenji Mitsui, Kohkichi Fukushima, Akira Ito, Kunihiko Shindo, Motonori Fukumura, Hiroshi Sakamoto, Shigeki Odagiri, Hideyuki Hasegawa, Makio Kurihara, Tadashi Takigami, Kaoru Oyama, Ryusaku Shimizu, Nobuo Oya, Mitsuru Hayase, Kaoru Shimokata, Masanori Morise, Osamu Kohnou, Masahiko Yamamoto, Takahiko Sugiura, Yoshio Torii, Mitsuru Iwakura, Keisuke Nishiwaki, Shuzo Sakai, Yoshihiro Senda, Yasuo Nomura, Yasutaka Ina, Manabu Asai, Mikiko Morita, Susumu Suetsugu, Saiji Yoshii, Masahito Kato, Kunio Nanjo, Joichi Kato, Saburo Kitaura, Kazuo Yoshitomo, Motoko Yamamoto, Masako Takizawa, Akihiko Kishimoto, Toshihiko Takeuchi, Toshiyuki Yamamoto, Kanzo Suzuki, Nobuo Maekawa, Michiyasu Nakanishi, Fumio Ito, Masayasu Yamazaki, Einosuke Ueda, Joichi Konishiike, Yoshinobu Konnai, Hisao Takahashi, Tadao Ochi, Shigenori Nakajima, Ohmi Takagi, Toru Niinaka, Yoshitaka Yamamoto, Kojiro Kondo, Fumio Miki, Fumio Miki, Hiroshi Okubo, Yuruko Okamoto, Keigo Maehara, Rinzo Soejima, Yoshihito Niki, Masayoshi Kawanishi, Eiro Tsubura, Toshihiro Goto, Yoshihiro Takishita, Yuji Higuchi, Yoshiro Sawae, Kaoru Okada, Toshiyuki Yanase, Nobuaki Shigematsu, Kazuyuki Higuchi, Nobuyoshi Miyazaki, Kohei Hara, Atsushi Saito, Keizo Yamaguchi, Yoji Suzuyama, Yoshiteru Shigeno, Hikaru Tanaka, Keizo Matsumoto, Yoshio Uzuka, Masato Hayashi, Hisao Kimura, Mineharu Sugimoto, Masayuki Ando, Hitoshi Nagano, Hiroharu Kondo, Kohji Mochizuki, Eriko Shigetoh, Reiko Nagao, Kenichi Matsuba, Atsushi Shinoda, Yoshiya Kitahara, Yosuke Egashira, Etsuo Kinuwaki, Kiyoshi Shima, Yoichi Hokamura, Toshiaki Yasutake, Yoshinobu Honda, Nozomu Kosakai, Jun Igari, Toyoko Oguri

研究成果: Article › 査読

抄録

The clinical effectiveness and safety of T-1982 were compared with those of cefmetazole (CMZ) in respiratory tract infections in the randomized double blind method. 289 patients were administered with one gram of T-1982 or two grams of CMZ by intravenous drip infusion twice a day for 14 days. The results were as follows; 1) Clinical efficacy rates were 87. 1% for T-1982 group and 83. 3% for CMZ group in overall cases; with 86.1% for T-1982 and 84.8% for CMZ in bacterial pneumonia, 77.8% for T-1982 and 83.3% for CMZ in mycoplasmal pneumonia or primary atypical pneumonia, and 88.1% for T-1982 and 82. \% for CMZ in the cases without pneumonia, respectively. Thus no significant difference was observed between the T-1982 group and the CMZ group. 2) The bacteriological responses of the patients to T-1982 and CMZ were favorable in 98. 2% and 98. 1%, respectively. No significant difference was observed. 3) No significant difference was noted between the two drug groups in incidence of adverse reaction. 4) As for the usefulness of the both treatment, committee judged to be useful with T-1982 in 82.1% of the cases and CMZ in 78.6%. Statistical tests showed no significant difference. From the results of this trial, it was concluded that T-1982 was as effective and as useful as CMZ in the treatment of respiratory tract infections as a 1/2 daily dose that of CMZ.

本文言語	English
ページ（範囲）	528-565
ページ数	38
ジャーナル	Chemotherapy
巻	31
号	5
DOI	https://doi.org/10.11250/chemotherapy1953.31.528
出版ステータス	Published - 1983 1月
外部発表	はい

ASJC Scopus subject areas

薬理学（医学）
感染症
薬理学
創薬
腫瘍学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

文献へのアクセス

10.11250/chemotherapy1953.31.528

他のファイルとリンク

引用スタイル

Fujimori, I., Kobayashi, Y., Sekita, K., Kato, Y., Saito, A., Ishikawa, K., Tomizawa, M., Nakayama, I., Nagahama, F., Onodera, S., Sakai, E., Nakabayashi, T., Koroku, T., Saito, T., Kuze, A., Mitsuhashi, O., Yasuda, M., Yaguchi, S., Kon, H., ... Oguri, T. (1983). Comparative Studies on the Effectiveness of T-1982 and That of Cefmetazole in Respiratory Tract Infections. Chemotherapy, 31(5), 528-565. https://doi.org/10.11250/chemotherapy1953.31.528

Fujimori, I, Kobayashi, Y, Sekita, K, Kato, Y, Saito, A, Ishikawa, K, Tomizawa, M, Nakayama, I, Nagahama, F, Onodera, S, Sakai, E, Nakabayashi, T, Koroku, T, Saito, T, Kuze, A, Mitsuhashi, O, Yasuda, M, Yaguchi, S, Kon, H, Watanabe, N, Shimomura, J, Sasaki, Y, Oshima, S, Takebe, K, Uehara, O, Sasaki, K, Kawabe, H, Tamura, T, Kimura, K, Baba, T, Kurihara, A, Masaki, N, Kosaka, S, Takishima, T, Konishi, K, Sakamoto, M, Konno, K, Oizumi, K, Watanabe, A, Hayashi, I, Takeda, H, Yamasaku, F, Suzuki, Y, Serine, O, Usuda, Y, Aoki, N, Katsu, M, Okui, S, Takizuka, H, Ogiwara, K, Aoyagi, T, Watanabe, S, Ueda, Y, Saito, A, Yamaji, T, Miyahara, T, Ikemoto, H, Watanabe, K, Kobayashi, H, Takeda, H, Kawamata, N, Nakagawa, K, Fukui, A, Kawaguchi, Y, Koyama, M, Yamamoto, T, Kin, K, Akiyoshi, R, Tanimoto, H, Nakada, K, Tachibana, A, Nakamori, Y, Chonabayashi, N, Shimada, K, Inamatsu, T, Mashimo, K, Yamaoka, S, Kabe, J, Ishibashi, Y, Fukaya, K, Higashi, F, Mitsui, K, Fukushima, K, Ito, A, Shindo, K, Fukumura, M, Sakamoto, H, Odagiri, S, Hasegawa, H, Kurihara, M, Takigami, T, Oyama, K, Shimizu, R, Oya, N, Hayase, M, Shimokata, K, Morise, M, Kohnou, O, Yamamoto, M, Sugiura, T, Torii, Y, Iwakura, M, Nishiwaki, K, Sakai, S, Senda, Y, Nomura, Y, Ina, Y, Asai, M, Morita, M, Suetsugu, S, Yoshii, S, Kato, M, Nanjo, K, Kato, J, Kitaura, S, Yoshitomo, K, Yamamoto, M, Takizawa, M, Kishimoto, A, Takeuchi, T, Yamamoto, T, Suzuki, K, Maekawa, N, Nakanishi, M, Ito, F, Yamazaki, M, Ueda, E, Konishiike, J, Konnai, Y, Takahashi, H, Ochi, T, Nakajima, S, Takagi, O, Niinaka, T, Yamamoto, Y, Kondo, K, Miki, F, Miki, F, Okubo, H, Okamoto, Y, Maehara, K, Soejima, R, Niki, Y, Kawanishi, M, Tsubura, E, Goto, T, Takishita, Y, Higuchi, Y, Sawae, Y, Okada, K, Yanase, T, Shigematsu, N, Higuchi, K, Miyazaki, N, Hara, K, Saito, A, Yamaguchi, K, Suzuyama, Y, Shigeno, Y, Tanaka, H, Matsumoto, K, Uzuka, Y, Hayashi, M, Kimura, H, Sugimoto, M, Ando, M, Nagano, H, Kondo, H, Mochizuki, K, Shigetoh, E, Nagao, R, Matsuba, K, Shinoda, A, Kitahara, Y, Egashira, Y, Kinuwaki, E, Shima, K, Hokamura, Y, Yasutake, T, Honda, Y, Kosakai, N, Igari, J & Oguri, T 1983, 'Comparative Studies on the Effectiveness of T-1982 and That of Cefmetazole in Respiratory Tract Infections', Chemotherapy, vol. 31, no. 5, pp. 528-565. https://doi.org/10.11250/chemotherapy1953.31.528

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title = "Comparative Studies on the Effectiveness of T-1982 and That of Cefmetazole in Respiratory Tract Infections",

abstract = "The clinical effectiveness and safety of T-1982 were compared with those of cefmetazole (CMZ) in respiratory tract infections in the randomized double blind method. 289 patients were administered with one gram of T-1982 or two grams of CMZ by intravenous drip infusion twice a day for 14 days. The results were as follows; 1) Clinical efficacy rates were 87. 1% for T-1982 group and 83. 3% for CMZ group in overall cases; with 86.1% for T-1982 and 84.8% for CMZ in bacterial pneumonia, 77.8% for T-1982 and 83.3% for CMZ in mycoplasmal pneumonia or primary atypical pneumonia, and 88.1% for T-1982 and 82. \% for CMZ in the cases without pneumonia, respectively. Thus no significant difference was observed between the T-1982 group and the CMZ group. 2) The bacteriological responses of the patients to T-1982 and CMZ were favorable in 98. 2% and 98. 1%, respectively. No significant difference was observed. 3) No significant difference was noted between the two drug groups in incidence of adverse reaction. 4) As for the usefulness of the both treatment, committee judged to be useful with T-1982 in 82.1% of the cases and CMZ in 78.6%. Statistical tests showed no significant difference. From the results of this trial, it was concluded that T-1982 was as effective and as useful as CMZ in the treatment of respiratory tract infections as a 1/2 daily dose that of CMZ.",

author = "Ippei Fujimori and Yoshio Kobayashi and Koujiro Sekita and Yasumichi Kato and Akira Saito and Kiyofumi Ishikawa and Masumi Tomizawa and Ichiro Nakayama and Fumio Nagahama and Sokichi Onodera and Eiichi Sakai and Takehito Nakabayashi and Tetsuji Koroku and Takahisa Saito and Akihiko Kuze and Osamu Mitsuhashi and Mitsuko Yasuda and Satoshi Yaguchi and Hiroshi Kon and Nobuo Watanabe and Jutaro Shimomura and Yuichi Sasaki and Shinichi Oshima and Kazuo Takebe and Osamu Uehara and Kazuo Sasaki and Hiroyasu Kawabe and Toyokazu Tamura and Kenichi Kimura and Tsuneharu Baba and Aiichiro Kurihara and Naoyoshi Masaki and Shiro Kosaka and Tamotsu Takishima and Kazuki Konishi and Masahiro Sakamoto and Kiyoshi Konno and Kotaro Oizumi and Akira Watanabe and Izumi Hayashi and Hajime Takeda and Fusanosuke Yamasaku and Yasutoshi Suzuki and Osamu Serine and Yoshimaru Usuda and Nobuki Aoki and Masataka Katsu and Shinji Okui and Hisashi Takizuka and Koji Ogiwara and Teruo Aoyagi and Sadatomo Watanabe and Yasushi Ueda and Atsushi Saito and Takehisa Yamaji and Tadashi Miyahara and Hideo Ikemoto and Kazuyoshi Watanabe and Hiroyuki Kobayashi and Hiroaki Takeda and Noriko Kawamata and Keiichi Nakagawa and Akira Fukui and Yoshiaki Kawaguchi and Masaru Koyama and Takashi Yamamoto and Kougin Kin and Ryuji Akiyoshi and Hiroichi Tanimoto and Koichiro Nakada and Akio Tachibana and Yoshitaka Nakamori and Naohiko Chonabayashi and Kaoru Shimada and Takashi Inamatsu and Keimei Mashimo and Sumio Yamaoka and Junzaburo Kabe and Yoshihiro Ishibashi and Kazufuto Fukaya and Fuyuhiko Higashi and Kenji Mitsui and Kohkichi Fukushima and Akira Ito and Kunihiko Shindo and Motonori Fukumura and Hiroshi Sakamoto and Shigeki Odagiri and Hideyuki Hasegawa and Makio Kurihara and Tadashi Takigami and Kaoru Oyama and Ryusaku Shimizu and Nobuo Oya and Mitsuru Hayase and Kaoru Shimokata and Masanori Morise and Osamu Kohnou and Masahiko Yamamoto and Takahiko Sugiura and Yoshio Torii and Mitsuru Iwakura and Keisuke Nishiwaki and Shuzo Sakai and Yoshihiro Senda and Yasuo Nomura and Yasutaka Ina and Manabu Asai and Mikiko Morita and Susumu Suetsugu and Saiji Yoshii and Masahito Kato and Kunio Nanjo and Joichi Kato and Saburo Kitaura and Kazuo Yoshitomo and Motoko Yamamoto and Masako Takizawa and Akihiko Kishimoto and Toshihiko Takeuchi and Toshiyuki Yamamoto and Kanzo Suzuki and Nobuo Maekawa and Michiyasu Nakanishi and Fumio Ito and Masayasu Yamazaki and Einosuke Ueda and Joichi Konishiike and Yoshinobu Konnai and Hisao Takahashi and Tadao Ochi and Shigenori Nakajima and Ohmi Takagi and Toru Niinaka and Yoshitaka Yamamoto and Kojiro Kondo and Fumio Miki and Fumio Miki and Hiroshi Okubo and Yuruko Okamoto and Keigo Maehara and Rinzo Soejima and Yoshihito Niki and Masayoshi Kawanishi and Eiro Tsubura and Toshihiro Goto and Yoshihiro Takishita and Yuji Higuchi and Yoshiro Sawae and Kaoru Okada and Toshiyuki Yanase and Nobuaki Shigematsu and Kazuyuki Higuchi and Nobuyoshi Miyazaki and Kohei Hara and Atsushi Saito and Keizo Yamaguchi and Yoji Suzuyama and Yoshiteru Shigeno and Hikaru Tanaka and Keizo Matsumoto and Yoshio Uzuka and Masato Hayashi and Hisao Kimura and Mineharu Sugimoto and Masayuki Ando and Hitoshi Nagano and Hiroharu Kondo and Kohji Mochizuki and Eriko Shigetoh and Reiko Nagao and Kenichi Matsuba and Atsushi Shinoda and Yoshiya Kitahara and Yosuke Egashira and Etsuo Kinuwaki and Kiyoshi Shima and Yoichi Hokamura and Toshiaki Yasutake and Yoshinobu Honda and Nozomu Kosakai and Jun Igari and Toyoko Oguri",

year = "1983",

month = jan,

doi = "10.11250/chemotherapy1953.31.528",

language = "English",

volume = "31",

pages = "528--565",

journal = "CHEMOTHERAPY",

issn = "0009-3165",

number = "5",

}

TY - JOUR

T1 - Comparative Studies on the Effectiveness of T-1982 and That of Cefmetazole in Respiratory Tract Infections

AU - Fujimori, Ippei

AU - Kobayashi, Yoshio

AU - Sekita, Koujiro

AU - Kato, Yasumichi

AU - Saito, Akira

AU - Ishikawa, Kiyofumi

AU - Tomizawa, Masumi

AU - Nakayama, Ichiro

AU - Nagahama, Fumio

AU - Onodera, Sokichi

AU - Sakai, Eiichi

AU - Nakabayashi, Takehito

AU - Koroku, Tetsuji

AU - Saito, Takahisa

AU - Kuze, Akihiko

AU - Mitsuhashi, Osamu

AU - Yasuda, Mitsuko

AU - Yaguchi, Satoshi

AU - Kon, Hiroshi

AU - Watanabe, Nobuo

AU - Shimomura, Jutaro

AU - Sasaki, Yuichi

AU - Oshima, Shinichi

AU - Takebe, Kazuo

AU - Uehara, Osamu

AU - Sasaki, Kazuo

AU - Kawabe, Hiroyasu

AU - Tamura, Toyokazu

AU - Kimura, Kenichi

AU - Baba, Tsuneharu

AU - Kurihara, Aiichiro

AU - Masaki, Naoyoshi

AU - Kosaka, Shiro

AU - Takishima, Tamotsu

AU - Konishi, Kazuki

AU - Sakamoto, Masahiro

AU - Konno, Kiyoshi

AU - Oizumi, Kotaro

AU - Watanabe, Akira

AU - Hayashi, Izumi

AU - Takeda, Hajime

AU - Yamasaku, Fusanosuke

AU - Suzuki, Yasutoshi

AU - Serine, Osamu

AU - Usuda, Yoshimaru

AU - Aoki, Nobuki

AU - Katsu, Masataka

AU - Okui, Shinji

AU - Takizuka, Hisashi

AU - Ogiwara, Koji

AU - Aoyagi, Teruo

AU - Watanabe, Sadatomo

AU - Ueda, Yasushi

AU - Saito, Atsushi

AU - Yamaji, Takehisa

AU - Miyahara, Tadashi

AU - Ikemoto, Hideo

AU - Watanabe, Kazuyoshi

AU - Kobayashi, Hiroyuki

AU - Takeda, Hiroaki

AU - Kawamata, Noriko

AU - Nakagawa, Keiichi

AU - Fukui, Akira

AU - Kawaguchi, Yoshiaki

AU - Koyama, Masaru

AU - Yamamoto, Takashi

AU - Kin, Kougin

AU - Akiyoshi, Ryuji

AU - Tanimoto, Hiroichi

AU - Nakada, Koichiro

AU - Tachibana, Akio

AU - Nakamori, Yoshitaka

AU - Chonabayashi, Naohiko

AU - Shimada, Kaoru

AU - Inamatsu, Takashi

AU - Mashimo, Keimei

AU - Yamaoka, Sumio

AU - Kabe, Junzaburo

AU - Ishibashi, Yoshihiro

AU - Fukaya, Kazufuto

AU - Higashi, Fuyuhiko

AU - Mitsui, Kenji

AU - Fukushima, Kohkichi

AU - Ito, Akira

AU - Shindo, Kunihiko

AU - Fukumura, Motonori

AU - Sakamoto, Hiroshi

AU - Odagiri, Shigeki

AU - Hasegawa, Hideyuki

AU - Kurihara, Makio

AU - Takigami, Tadashi

AU - Oyama, Kaoru

AU - Shimizu, Ryusaku

AU - Oya, Nobuo

AU - Hayase, Mitsuru

AU - Shimokata, Kaoru

AU - Morise, Masanori

AU - Kohnou, Osamu

AU - Yamamoto, Masahiko

AU - Sugiura, Takahiko

AU - Torii, Yoshio

AU - Iwakura, Mitsuru

AU - Nishiwaki, Keisuke

AU - Sakai, Shuzo

AU - Senda, Yoshihiro

AU - Nomura, Yasuo

AU - Ina, Yasutaka

AU - Asai, Manabu

AU - Morita, Mikiko

AU - Suetsugu, Susumu

AU - Yoshii, Saiji

AU - Kato, Masahito

AU - Nanjo, Kunio

AU - Kato, Joichi

AU - Kitaura, Saburo

AU - Yoshitomo, Kazuo

AU - Yamamoto, Motoko

AU - Takizawa, Masako

AU - Kishimoto, Akihiko

AU - Takeuchi, Toshihiko

AU - Yamamoto, Toshiyuki

AU - Suzuki, Kanzo

AU - Maekawa, Nobuo

AU - Nakanishi, Michiyasu

AU - Ito, Fumio

AU - Yamazaki, Masayasu

AU - Ueda, Einosuke

AU - Konishiike, Joichi

AU - Konnai, Yoshinobu

AU - Takahashi, Hisao

AU - Ochi, Tadao

AU - Nakajima, Shigenori

AU - Takagi, Ohmi

AU - Niinaka, Toru

AU - Yamamoto, Yoshitaka

AU - Kondo, Kojiro

AU - Miki, Fumio

AU - Okubo, Hiroshi

AU - Okamoto, Yuruko

AU - Maehara, Keigo

AU - Soejima, Rinzo

AU - Niki, Yoshihito

AU - Kawanishi, Masayoshi

AU - Tsubura, Eiro

AU - Goto, Toshihiro

AU - Takishita, Yoshihiro

AU - Higuchi, Yuji

AU - Sawae, Yoshiro

AU - Okada, Kaoru

AU - Yanase, Toshiyuki

AU - Shigematsu, Nobuaki

AU - Higuchi, Kazuyuki

AU - Miyazaki, Nobuyoshi

AU - Hara, Kohei

AU - Saito, Atsushi

AU - Yamaguchi, Keizo

AU - Suzuyama, Yoji

AU - Shigeno, Yoshiteru

AU - Tanaka, Hikaru

AU - Matsumoto, Keizo

AU - Uzuka, Yoshio

AU - Hayashi, Masato

AU - Kimura, Hisao

AU - Sugimoto, Mineharu

AU - Ando, Masayuki

AU - Nagano, Hitoshi

AU - Kondo, Hiroharu

AU - Mochizuki, Kohji

AU - Shigetoh, Eriko

AU - Nagao, Reiko

AU - Matsuba, Kenichi

AU - Shinoda, Atsushi

AU - Kitahara, Yoshiya

AU - Egashira, Yosuke

AU - Kinuwaki, Etsuo

AU - Shima, Kiyoshi

AU - Hokamura, Yoichi

AU - Yasutake, Toshiaki

AU - Honda, Yoshinobu

AU - Kosakai, Nozomu

AU - Igari, Jun

AU - Oguri, Toyoko

PY - 1983/1

Y1 - 1983/1

N2 - The clinical effectiveness and safety of T-1982 were compared with those of cefmetazole (CMZ) in respiratory tract infections in the randomized double blind method. 289 patients were administered with one gram of T-1982 or two grams of CMZ by intravenous drip infusion twice a day for 14 days. The results were as follows; 1) Clinical efficacy rates were 87. 1% for T-1982 group and 83. 3% for CMZ group in overall cases; with 86.1% for T-1982 and 84.8% for CMZ in bacterial pneumonia, 77.8% for T-1982 and 83.3% for CMZ in mycoplasmal pneumonia or primary atypical pneumonia, and 88.1% for T-1982 and 82. \% for CMZ in the cases without pneumonia, respectively. Thus no significant difference was observed between the T-1982 group and the CMZ group. 2) The bacteriological responses of the patients to T-1982 and CMZ were favorable in 98. 2% and 98. 1%, respectively. No significant difference was observed. 3) No significant difference was noted between the two drug groups in incidence of adverse reaction. 4) As for the usefulness of the both treatment, committee judged to be useful with T-1982 in 82.1% of the cases and CMZ in 78.6%. Statistical tests showed no significant difference. From the results of this trial, it was concluded that T-1982 was as effective and as useful as CMZ in the treatment of respiratory tract infections as a 1/2 daily dose that of CMZ.

AB - The clinical effectiveness and safety of T-1982 were compared with those of cefmetazole (CMZ) in respiratory tract infections in the randomized double blind method. 289 patients were administered with one gram of T-1982 or two grams of CMZ by intravenous drip infusion twice a day for 14 days. The results were as follows; 1) Clinical efficacy rates were 87. 1% for T-1982 group and 83. 3% for CMZ group in overall cases; with 86.1% for T-1982 and 84.8% for CMZ in bacterial pneumonia, 77.8% for T-1982 and 83.3% for CMZ in mycoplasmal pneumonia or primary atypical pneumonia, and 88.1% for T-1982 and 82. \% for CMZ in the cases without pneumonia, respectively. Thus no significant difference was observed between the T-1982 group and the CMZ group. 2) The bacteriological responses of the patients to T-1982 and CMZ were favorable in 98. 2% and 98. 1%, respectively. No significant difference was observed. 3) No significant difference was noted between the two drug groups in incidence of adverse reaction. 4) As for the usefulness of the both treatment, committee judged to be useful with T-1982 in 82.1% of the cases and CMZ in 78.6%. Statistical tests showed no significant difference. From the results of this trial, it was concluded that T-1982 was as effective and as useful as CMZ in the treatment of respiratory tract infections as a 1/2 daily dose that of CMZ.

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U2 - 10.11250/chemotherapy1953.31.528

DO - 10.11250/chemotherapy1953.31.528

M3 - Article

AN - SCOPUS:0020564509

VL - 31

SP - 528

EP - 565

JO - CHEMOTHERAPY

JF - CHEMOTHERAPY

SN - 0009-3165

IS - 5

ER -

Comparative Studies on the Effectiveness of T-1982 and That of Cefmetazole in Respiratory Tract Infections

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