The activity of S-4661, a new parenteral carbapenem antibiotic, was evaluated against 202 recent clinical isolates of respiratory pathogens. S-4661 was similar to or 2 times more active than imipenem, meropenem, and biapenem, and 8-128 times more active than ceftazidime against gram-positive bacteria. Against gram-negative bacteria, S-4661 was slightly less active than meropenem, but 2-8 times more active than the other agents. In particular, against Pseudomonas aeruginosa S-4661 showed the most potent activity. Th us it was found that S-4661 possesses a potent and well-balanced activity against respiratory pathogens. Copyright (C) 2000 S. Karger AG, Basel.
|出版ステータス||Published - 2000 1月 1|
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