Comparative analysis of clinical outcomes after allogeneic bone marrow transplantation versus peripheral blood stem cell transplantation from a related donor in Japanese patients

Tetsuya E. Tanimoto, Takuhiro Yamaguchi, Yuji Tanaka, Akiko Saito, Kinuko Tajima, Takahiro Karasuno, Masanobu Kasai, Kenji Kishi, Takehiko Mori, Nobuo Maseki, Satoko Morishima, Shigesaburo Miyakoshi, Masaharu Kasai, Yuju Ohno, Sung Won Kim, Akihiko Numata, Masahiro Kami, Yoichi Takaue, Shinichiro Mori, Mine Harada

研究成果: Article査読

28 被引用数 (Scopus)

抄録

A reduced incidence of graft versus host disease (GvHD) has been documented among Japanese allogeneic bone marrow transplantation (BMT) patients, as the Japanese are genetically more homogeneous than western populations. To clarify whether this ethnic difference affects the results of allogeneic peripheral blood stem cell transplantation (PBSCT), we conducted a nationwide survey to compare clinical outcomes of allogeneic PBSCT (n = 214) and BMT (n = 295) from a human leucocyte antigen-identical-related donor in Japanese patients. The cumulative incidence of grades II-IV acute GvHD was 37.4% for PBSCT and 32.0% for BMT. The cumulative incidence of extensive chronic GvHD at 1 year was significantly higher after PBSCT than BMT (42% vs. 27%; P < 0.01). The organ involvement patterns of GvHD were different between the two groups. By multivariate analyses, the incidence of chronic GvHD was significantly increased in PBSCT, whereas the stem cell source did not affect the incidence of acute GvHD, transplant-related mortality, relapse or survival. We concluded that Japanese PBSCT patients have an increased risk of chronic GvHD compared with BMT patients, but the incidence of acute GvHD was still lower than in western populations. Thus, the choice of haematopoietic stem cell source should be considered based on data for individual ethnic populations.

本文言語English
ページ(範囲)480-493
ページ数14
ジャーナルBritish Journal of Haematology
125
4
DOI
出版ステータスPublished - 2004 5
外部発表はい

ASJC Scopus subject areas

  • Hematology

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