Combined brønsted-base-mediated direct C-H carboxylation of heteroarenes with CO2

Masanori Shigeno, Keita Sasaki, Kazuya Hanasaka, Itsuki Tohara, Kanako Nozawa-Kumada, Yoshinori Kondo

研究成果: Review article査読

抄録

This review article summarizes that the combined Brønsted-base system comprising LiO-t-Bu, CsF, and 18-crown-6 efficiently proceeds the direct carboxylation of electron-rich heteroarenes, such as benzothiophene and benzofuran, with CO2. Good functional group compatibility is displayed, allowing the use of Me, MeO, halogen, CN, ketone, and amide moieties. 3-Substituted indoles are also used for C-2 carboxylation, while double-carboxylation of 2-alkylheteroarenes is achieved by LiO-t-Bu and CsF.

本文言語English
ジャーナルHeterocycles
103
2
DOI
出版ステータスPublished - 2021

ASJC Scopus subject areas

  • 分析化学
  • 薬理学
  • 有機化学

フィンガープリント

「Combined brønsted-base-mediated direct C-H carboxylation of heteroarenes with CO2」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル