Combination chemotherapy with nedaplatin and 5-fluorouracil for oral squamous cell carcinomas

Kaoru Yamaoka, Masayuki Fukuda, Seiichi Kuwajima, Hisako Hagiwara, Shinichi Toshima, Atsushi Matsuoka, Takayoshi Ohnuki, Hiroshi Seki, Hirokazu Nagai, Mitsuyoshi Iino, Masato Sageshima

研究成果: Article査読

4 被引用数 (Scopus)

抄録

We used a new combination chemotherapy with nedaplatin (CDGP) and 5-fluorouracil (5-FU) in eleven fresh patients with oral squamous cell carcinomas. 5-FU was administered at a dose of 1,000 mg/body by continuous infusion for 24 hours on days 1 to 5. CDGP was administered at a dose of 80 or 100 mg/m2 by drip infusion for 120 minutes on day 5. The response rates of total (1- or 2-course) and 2-course group were 54. 5% and 83.3%, respectively. Adverse drug reactions were limited to two cases of grade 3 toxicity with anorexia. The combination chemotherapy with 5-FU and CDGP in place of cisplatin and 5-FU seemed to play an important role as neo-adjuvant chemotherapy for oral squamous cell carcinomas.

本文言語English
ページ(範囲)951-955
ページ数5
ジャーナルGan to kagaku ryoho. Cancer & chemotherapy
30
7
出版ステータスPublished - 2003 7
外部発表はい

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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