Combination chemotherapy of carboplatin and cytosine arabinoside for high-risk leukemia: A pilot study

Noriaki Iwao, Minoru Yoshida, Kiyohiko Hatake, Yoshiaki Hoshino, Shoutaro Hagiwara, Hiroshi Tomizuka, Ritsuko Shimizu, Toshiyuki Suzuki, Yusuke Furukawa, Norio Komatsu, Kazuo Muroi, Akiyoshi Miwa, Shinobu Sakamoto, Yasusada Miura

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Fourteen patients with high-risk leukemia (six with relapsed AML, three with relapsed ALL, one with AML-M0, four with CML in myeloid blastic crisis) were treated with a combination chemotherapy of carboplatin (200-300 mg/m2/day) and cytosine arabinoside (100 mg/m2/day) by 24 h continuous infusion for 5-7 days. Five patients (35.7%) achieved complete remission including two patients complicated with myelofibrosis (one with AML-M0 and one with CML in myelo-megakaryocytic crisis). Thirteen patients had nausea and vomiting, five patients had severe, prolonged neutropenia for which it was necessary to administer granulocyte colony-stimulating factor and six patients had severe thrombocytopenia. We concluded that this regimen is effective for the treatment of high-risk leukemia.

本文言語English
ページ(範囲)899-903
ページ数5
ジャーナルLeukemia Research
19
12
DOI
出版ステータスPublished - 1995 12月
外部発表はい

ASJC Scopus subject areas

  • 血液学
  • 腫瘍学
  • 癌研究

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