Colony-stimulating factor-producing tumours: Production of granulocyte colony-stimulating factor and interleukin-6 is secondary to interleukin-1 production

R. Tsuyuoka, T. Takahashi, Y. Sasaki, Y. Taniguchi, M. Fukumoto, A. Suzuki, K. Nakamura, S. Kobayashi, T. Kudo, K. Nakao

研究成果: Article査読

17 被引用数 (Scopus)

抄録

We have reported that tumours producing colony-stimulating factor (CSF) also secrete interleukin-1 (IL-1) and IL-6. In the present study, we characterised the role played by IL-1 in CSF production. IL-1 receptor antagonist inhibited the production of granulocyte (G)-CSF and IL-6 by approximately 90% in CSF-producing human lung carcinoma cell lines. Similar results were obtained with hydrocortisone, which suppresses IL-1 gene expression. In contrast, 15 non-CSF-producing human lung carcinoma cell lines did not show detectable IL-1 production, although seven of them were induced to produce G-CSF and IL-6 by exogenous IL-1α. Cell lines that responded to IL-1α, including the CSF-producing lines, expressed receptors for IL-1α. These results indicate that CSF-producing tumours can be characterised by their constitutive IL-1 production, IL-1 receptor expression and IL-1-dependent excess production of G-CSF and IL-6. Furthermore, transcription factor(s) may be involved in the abnormal IL-1α production.

本文言語English
ページ(範囲)2130-2136
ページ数7
ジャーナルEuropean Journal of Cancer
30
14
DOI
出版ステータスPublished - 1994
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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