Cobalt-catalyzed ortho alkylation of aromatic imines with primary and secondary alkyl halides

研究成果: Article査読

130 被引用数 (Scopus)

抄録

We report here cobalt-N-heterocyclic carbene catalytic systems for the ortho alkylation of aromatic imines with alkyl chlorides and bromides, which allows the introduction of a variety of primary and secondary alkyl groups at room temperature. The stereochemical outcomes of the reaction of secondary alkyl halides suggest that the present reaction involves single-electron transfer from a cobalt species to the alkyl halide to generate the corresponding alkyl radical. A cycloalkylated product obtained by this method can be transformed into unique spirocycles through manipulation of the directing and cycloalkyl groups.

本文言語English
ページ(範囲)9279-9282
ページ数4
ジャーナルJournal of the American Chemical Society
135
25
DOI
出版ステータスPublished - 2013 6 26
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)
  • 生化学
  • コロイド化学および表面化学

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