Cobalt-catalyzed ortho-alkenylation of aromatic aldimines via chelation-assisted C-H bond activation

Takeshi Yamakawa, Naohiko Yoshikai

研究成果: Article査読

26 被引用数 (Scopus)

抄録

An ortho-alkenylation reaction of an aromatic aldimine with an internal alkyne is efficiently promoted by a cobalt catalyst generated from CoBr 2, triarylphosphine, and iPrMgBr. The reaction takes place under mild room-temperature conditions to afford, upon acidic hydrolysis, a variety of ortho-alkenylated aromatic aldehydes in moderate to excellent yields. The neighboring formyl and alkenyl groups in the product can be utilized as synthetic handles for the facile construction of indene and naphthalene carbocycles.

本文言語English
ページ(範囲)4459-4465
ページ数7
ジャーナルTetrahedron
69
22
DOI
出版ステータスPublished - 2013 6 3
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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