Cobalt-catalyzed directed: Ortho -methylation of arenes with methyl tosylate

研究成果: Article査読

16 被引用数 (Scopus)

抄録

A cobalt-catalyzed directed ortho C-H methylation reaction of arenes has been achieved using readily available methyl tosylate as a methylating agent. An in situ-generated cobalt-N-heterocyclic carbene catalyst in combination with neopentylmagnesium bromide promotes the methylation at room temperature. The reaction is applicable to various substrates bearing nitrogen directing groups such as N-aryl imine, N-H imine, and 2-pyridyl groups. The present protocol also allows for facile introduction of a trideuteriomethyl group into arenes.

本文言語English
ページ(範囲)2214-2218
ページ数5
ジャーナルOrganic Chemistry Frontiers
5
14
DOI
出版ステータスPublished - 2018 7月 21
外部発表はい

ASJC Scopus subject areas

  • 有機化学

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