Cobalt-catalyzed directed alkylation of arenes with primary and secondary alkyl halides

研究成果: Article査読

12 被引用数 (Scopus)

抄録

A cobalt-N-heterocyclic carbene catalyst allows ortho-alkylation of aromatic imines with unactivated primary and secondary alkyl chlorides and bromides under room-temperature conditions. The scope of the reaction encompasses or complements that of cobalt-catalyzed ortho-alkylation reactions with olefins as alkylating agents that we developed previously. Stereochemical outcomes of secondary alkylation reactions suggest that the reaction involves single-electron transfer from a cobalt species to the alkyl halide to generate the corresponding alkyl radical. A cycloalkylated product obtained by this method can be transformed into unique spirocycles through manipulation of the directing group and the cycloalkyl groups.

本文言語English
ページ(範囲)419-424
ページ数6
ジャーナルPure and Applied Chemistry
86
3
DOI
出版ステータスPublished - 2014 3 20
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)
  • 化学工学(全般)

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