Clopidogrel resistance in Japanese patients scheduled for percutaneous coronary intervention

Kozo Hoshino, Hisanori Horiuchi, Tomohisa Tada, Junichi Tazaki, Eiichiro Nishi, Mitsunori Kawato, Tomoyuki Ikeda, Hiromi Yamamoto, Masaharu Akao, Yutaka Furukawa, Satoshi Shizuta, Masanao Toma, Toshihiro Tamura, Naritatsu Saito, Takahiro Doi, Neiko Ozasa, Toshikazu Jinnai, Kanako Takahashi, Haruyo Watanabe, Yuka YoshikawaNaoko Nishimoto, Chiho Ouchi, Takeshi Morimoto, Toru Kita, Takeshi Kimura

研究成果: Article査読

51 被引用数 (Scopus)

抄録

Background Dual antiplatelet therapy with acetylsalicylic acid (ASA) and a P2Y12 ADP-receptor blocker is standard for prevention of coronary stent thrombosis. Clopidogrel, a 2nd-generation P2Y12 blocker, has recently become available in Japan and this study aimed to evaluate its antiplatelet effects in Japanese patients. Methods and Results Thirty Japanese patients scheduled for elective coronary stent implantation were enrolled. Under low-dose ASA therapy, 300 mg clopidogrel was loaded on the 1st day and a daily 75-mg dose was administered on the following days. Assessed by optical aggregometer, rapid inhibition occurred at 4 h, when the inhibition of platelet aggregation rate (IPA) was 16.4±12.8% using 5 μmol/L ADP as the stimulus. The antiplatelet efficacy of clopidogrel was reasonably constant in each patient throughout the study period, although there was a broad inter-individual variation. At 48 h after clopidogrel loading, the ratios of responders (IPA ≥30%), hypo-responders (10%≤IPA<30%), and non-responders (IPA <10%) were 36%, 50%, and 14%, respectively. Conclusions The antiplatelet effectiveness of clopidogrel appeared individual-specific with wide inter-individual variation. The rate of clopidogrel non-responders was 14% among the examined Japanese patients. (Circ J 2009; 73: 336 - 342).

本文言語English
ページ(範囲)336-342
ページ数7
ジャーナルCirculation Journal
73
2
DOI
出版ステータスPublished - 2009
外部発表はい

ASJC Scopus subject areas

  • 循環器および心血管医学

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