Cloning of a housekeeping-type gene (MERS) preferentially expressed in murine erythroleukemia cells

Yamamoto Tohru, Matsui Yasuhisa, Natori Shunji, Obinata Masuo

研究成果: Article査読

110 被引用数 (Scopus)

抄録

DNA complementary to mRNA preferentially produced in murine erythroleukemia (MEL) cells was cloned from a cDNA library of anemic mouse spleen mRNAs. An open reading frame was noted in the cloned DNA, and was tentatively designated MER5. The MER5 mRNA is abundant in three MEL cell Unes, but less in other tissues or cell lines. The levels of the MER5 mRNA changed periodically during MEL cell differentiation and decreased as globin mRNA accumulated. The MER5 promoter region contained no typical TATA-like sequence, but possible target sequences for API, AP2, SP1 and octamer-binding protein. More interestingly, this promoter contained the duplicated CACCC boxes, which are common in the adult β-globin promoter from many species, but uncommon for promoters of other eukaryotic genes.

本文言語English
ページ(範囲)337-343
ページ数7
ジャーナルGene
80
2
DOI
出版ステータスPublished - 1989 8月 15

ASJC Scopus subject areas

  • 遺伝学

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