TY - JOUR
T1 - Cloning, mapping and expression of PEBP2αC, a third gene encoding the mammalian Runt domain
AU - Bae, Suk Chul
AU - Takahashi, Ei ichi
AU - Zhang, Yu Wen
AU - Ogawa, Eiko
AU - Shigesada, Katsuya
AU - Namba, Yuziro
AU - Satake, Masanobu
AU - Ito, Yoshiaki
N1 - Funding Information:
This research was supported in part by Grants-in-Aid for Special Project Research on Cancer Bio-Science for Cancer Research to Y.I. S-C.B. and E.O. were supported by the postdoctoral fellowship from the Japan Society for the Promotion of Science.
PY - 1995
Y1 - 1995
N2 - PEBP2/CBF is a heterodimeric transcription factor composed of α and β subunits. Previously, we reported two distinct mouse genes, PEBP2αA and PEBP2αB, which encode the α subunit. PEBP2αB is the homologue of human AML1, encoding the acute myeloid leukemia 1 protein. AMLI and human PEBP2/CBFβ were detected independently at the breakpoints of two characteristic chromosome translocations observed frequently in two subtypes of acute myeloid leukemia. The PEBP2α proteins contain a 128-amino-acid (aa) region highly homologous to the Drosophila melanogaster segmentation gene runt. The evolutionarily conserved region, named the Runt domain, harbors DNA-binding and heterodimerizing activities. In this study, we identified the third Runt-domain-encoding gene, PEBP2αC, which maps to lp36.11-p36.13 in the human chromosome and encodes a 415-aa protein. PEBP2αC forms a heterodimer with PEBP2β, binds to the PEBP2 site and transactivates transcription, similar to PEBP2αA and PEBP2αB.
AB - PEBP2/CBF is a heterodimeric transcription factor composed of α and β subunits. Previously, we reported two distinct mouse genes, PEBP2αA and PEBP2αB, which encode the α subunit. PEBP2αB is the homologue of human AML1, encoding the acute myeloid leukemia 1 protein. AMLI and human PEBP2/CBFβ were detected independently at the breakpoints of two characteristic chromosome translocations observed frequently in two subtypes of acute myeloid leukemia. The PEBP2α proteins contain a 128-amino-acid (aa) region highly homologous to the Drosophila melanogaster segmentation gene runt. The evolutionarily conserved region, named the Runt domain, harbors DNA-binding and heterodimerizing activities. In this study, we identified the third Runt-domain-encoding gene, PEBP2αC, which maps to lp36.11-p36.13 in the human chromosome and encodes a 415-aa protein. PEBP2αC forms a heterodimer with PEBP2β, binds to the PEBP2 site and transactivates transcription, similar to PEBP2αA and PEBP2αB.
KW - AML1
KW - Human cDNA
KW - chromosome translocation
KW - transcription factor
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U2 - 10.1016/0378-1119(95)00060-J
DO - 10.1016/0378-1119(95)00060-J
M3 - Article
C2 - 7622058
AN - SCOPUS:0029016934
VL - 159
SP - 245
EP - 248
JO - Gene
JF - Gene
SN - 0378-1119
IS - 2
ER -