Clinicopathological study of interstitial foam cells in idiopathic membranous nephropathy - Consideration of the appearance of interstitial foam cells in renal tissue

Isao Kurihara, Takao Saito, Osamu Hotta, Yoshio Taguma, Katsuhiko Sudo, Ikuo Horigome, Sigemi Chiba, Takako Munakata, Jun Soma, Tetsuya Ootaka, Hiroshi Sato, Keishi Abe

研究成果: Article査読

抄録

We conducted an immunohistological investigation on the pathogenesis of interstitial foam cell formation in patients with idiopathic membranous nephropathy (MN). The patients were divided into two groupsGroup I consisted of 23 MN patients with interstitial foam cells; Group II consisted of the other 159 patients without foam cells. Age at renal biopsy, duration of proteinuria, blood pressure and other clinical parameters were not significantly different between the two groups. The proportion of nephrotic patients in Group I was 52.2% (12/23), and was not significantly different from that in Group II (48.4%, 77/159). Renal biopsy specimens were examined by immunoperoxidase studies using monoclonal antibodies. The interstitial foam cells were positive for EBM11 (CD68) and 25F9, which are markers of macrophage (M φ ) and mature M φ, respectively, but did not express markers of T cells. In interstitial infiltrating cells, both M φ and T cells were observed, but mature M φ were seldom seen. Furthermore, LFA-1 and ICAM-1, but not ICAM-3 (the third ligand for LFA-1) were observed in the interstitial foam cells. LFA-1 and ICAM-3 were observed mainly in interstitial infiltrating cells, but ICAM-1 was observed to a much lesser extent in these cells. These results suggest that interstitial foam cells in MN may be independent of severe hyperlipidemia and proteinuria, and that there may be different mechanisms underlying the accumulation of interstitial foam cells and infiltrating m φ s. Further investigations are required to clarify the pathogenesis of interstitial foam cells in renal tissue.

本文言語English
ページ(範囲)84-90
ページ数7
ジャーナルJapanese Journal of Nephrology
38
2
出版ステータスPublished - 1996

ASJC Scopus subject areas

  • 腎臓病学

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