Clinicopathological analysis of nine consecutive central nervous system primitive neuroectodermal tumors in a single institute

Misaki Aizawa-Kohama, Toshihiro Kumabe, Ryuta Saito, Masayuki Kanamori, Yoji Yamashita, Yukihiko Sonoda, Mika Watanabe, Teiji Tominaga

研究成果: Article

2 引用 (Scopus)

抜粋

The objective of this study was to determine the outcome of central nervous system primitive neuroectodermal tumors (CNS PNETs) and to clarify the histopathological findings as prognostic factors. We performed a retrospective analysis of nine consecutive patients with CNS PNETs who underwent treatment at our institute between 1993 and 2011. All patients were treated by surgical resection followed by chemoradiotherapy. Additional treatment, including surgical resection, was performed at relapse. Expression of immunohistochemical markers was examined for neuronal, astrocytic, mesenchymal, and epithelial differentiation, and also for TP53, O6-methylguanine-DNA methyltransferase, and Ki-67. Five-year progression-free survival was 18.2 % and the overall survival was 52.5 %. Five the 9 patients had recurrence and 4 patients died during the median follow-up period of 41.1 months. All 4 patients died of dissemination not local recurrence. After relapses, the extent of differentiation was different in each case and TP53 changed to positive or negative, but the Ki-67 labeling index did not reveal any differences between primary and recurrent tumors. A treatment procedure to prevent and treat dissemination of CNS PNETs should be established. Because the pathological change after relapse was different in each case, definitive histopathological prognostic factors for CNS PNETs are still difficult to propose.

元の言語English
ページ(範囲)15-27
ページ数13
ジャーナルBrain Tumor Pathology
30
発行部数1
DOI
出版物ステータスPublished - 2013 1 1

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

フィンガープリント Clinicopathological analysis of nine consecutive central nervous system primitive neuroectodermal tumors in a single institute' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用