Clinical validity of the Japanese version of the Functional Assessment of Cancer Therapy-Anemia Scale

Maya Kurita, Kojiro Shimozuma, Satoshi Morita, Yuki Fujiki, Kenichi Ishizawa, Hisae Eguchi, Yuko Saito, Nobuko Ushirozawa, Izumi Wasada, Yasuo Ohashi, Kenji Eguchi

    研究成果: Article査読

    3 被引用数 (Scopus)

    抄録

    Goals of work: The purpose of this study was to reveal the clinical validity of the Japanese version of the Functional Assessment of Cancer Therapy-Anemia scale (FACT-An) in relation to hemoglobin level. We also analyzed patients' scores for the related FACT-General scale (FACT-G), the FACT Anemia subscale, and the FACT Trial Outcome Index-Anemia scale (FACT TOI-An) to determine which was the most sensitive to anemia measurements. Materials and methods: Throughout Japan, we recruited 227 patients (mean±SD, 59±12.1 years old) diagnosed with a variety of cancers. We correlated the severity of anemia, as measured by hemoglobin levels, to scores on the FACT-An and on the other scales at baseline and at 3 months. Main results: The questionnaire completion rate was more than 98% at both time points. The FACT-An had high internal consistency (Cronbach's alpha coefficient >0.8). FACT-An scores were significantly and positively correlated with hemoglobin levels both at baseline (r=0.24; 95% CI=0.12 to 0.36; n=225) and at 3 months (r=0.24; 95% CI=0.10 to 0.36; n=204). FACT-G, FACT Anemia subscale, and FACT TOI-An scores also successfully discriminated between patients with lower (Hb <11.0 g/dl) and higher (Hb ≥11.0 g/dl) hemoglobin levels. Moreover, the changes of these FACT scores over 3-months could discriminate changes in hemoglobin level. Conclusion: The Japanese version of the FACT-An has higher clinical validity and can be used to appropriately assess health-related quality of life among Japanese cancer patients with anemia.

    本文言語English
    ページ(範囲)1-6
    ページ数6
    ジャーナルSupportive Care in Cancer
    15
    1
    DOI
    出版ステータスPublished - 2007 1

    ASJC Scopus subject areas

    • 腫瘍学

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