Clinical Presentation, Management and Outcome of Japanese Patients with Acute Myocardial Infarction in the Troponin era – Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) –

Masaharu Ishihara, Masashi Fujino, Hisao Ogawa, Satoshi Yasuda, Teruo Noguchi, Koichi Nakao, Yukio Ozaki, Kazuo Kimura, Satoru Suwa, Kazuteru Fujimoto, Yasuharu Nakama, Takashi Morita, Wataru Shimizu, Yoshihiko Saito, Kennichi Tsujita, Kunihiko Nishimura, Yoshihiro Miyamoto

研究成果: Article査読

61 被引用数 (Scopus)

抄録

Background: New criteria for diagnosis of acute myocardial infarction (AMI) were proposed in 2000 as a universal definition, in which cardiac troponin (cTn) was the preferred biomarker. A large number of patients formerly classified by creatine kinase (CK) as unstable angina are now ruled-in by cTn as non-ST-elevation myocardial infarction (NSTEMI). Methods and Results: The Japanese registry of acute Myocardial INfarction diagnosed by Universal dEfiniTion (J-MINUET) is a prospective and multicenter registry conducted in 28 institutions. We enrolled 3,283 consecutive patients with AMI diagnosed by cTn-based criteria who were admitted to participating institutions within 48 h of symptom onset. There were 2,262 patients (68.9%) with STEMI and 1,021 (31.1%) with NSTEMI. CK was not elevated more than twice the upper limit of normal in 458 patients (44.9%) with NSTEMI (NSTEMI-CK). Although there was no significant difference in the in-hospital mortality of STEMI and NSTEMI with CK elevation (NSTEMI+CK) patients (7.1% vs. 7.8%, P=0.57), it was significantly lower in patients with NSTEMI-CK than in those with STEMI or NSTEMI+CK (1.7%, P<0.001 for each). Conclusions: J-MINUET revealed the clinical presentation, management and outcomes of Japanese patients with AMI in the current cTn era. We should be aware of the difference between AMI diagnosed by CK-based criteria and AMI diagnosed by cTn-based criteria when using universal definitions for the diagnosis of AMI.

本文言語English
ページ(範囲)1255-1262
ページ数8
ジャーナルCirculation Journal
79
6
DOI
出版ステータスPublished - 2015 5 11
外部発表はい

ASJC Scopus subject areas

  • 循環器および心血管医学

フィンガープリント

「Clinical Presentation, Management and Outcome of Japanese Patients with Acute Myocardial Infarction in the Troponin era – Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) –」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル