Clinical outcomes of resectable esophageal cancer with supraclavicular lymph node metastases treated with curative intent

Yoshitaka Honma, Nobukazu Hokamura, Kengo Nagashima, Kazuki Sudo, Hirokazu Shoji, Satoru Iwasa, Atsuo Takashima, Ken Kato, Tetsuya Hamaguchi, Narikazu Boku, Rei Umezawa, Yoshinori Ito, Jun Itami, Kazuo Koyanagi, Hiroyasu Igaki, Yuji Tachimori

研究成果: Article

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Background: In the seventh edition of the Union for International Cancer Control (UICC) TNM classification, supraclavicular lymph node (SCLN) in regard to thoracic esophageal cancer (EC) is regarded as a distant organ, therefore, if resectable, SCLN metastasis is considered a candidate for systemic chemotherapy. The purpose of this study was to clarify the survival outcome in patients with resectable thoracic EC with SCLN metastases (M1LYM) treated with curative intent. Patients and Methods: Clinical outcomes in patients with resectable thoracic EC with SCLN metastases (M1LYM) treated by esophagectomy or definitive chemoradiotherapy (dCRT) were retrospectively analyzed. Results: A total of 102 patients were divided in three groups: Surgery with perioperative therapy, n=45; surgery alone, n=19; and dCRT, n=38. Overall, median progression-free survival and median survival time were 9.3 and 26.7 months, respectively. The median survival time was 27.5 months in the group treated with surgery with perioperative treatment, 50.6 months in those treated with surgery alone, and 22 months in the dCRT group. No significant survival difference was seen among the three groupS. Conclusion: Over 30% of patients with resectable M1LYM treated with curative intent achieved long-term survival.

元の言語English
ページ(範囲)3741-3749
ページ数9
ジャーナルAnticancer research
37
発行部数7
DOI
出版物ステータスPublished - 2017 7
外部発表Yes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

フィンガープリント Clinical outcomes of resectable esophageal cancer with supraclavicular lymph node metastases treated with curative intent' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Honma, Y., Hokamura, N., Nagashima, K., Sudo, K., Shoji, H., Iwasa, S., Takashima, A., Kato, K., Hamaguchi, T., Boku, N., Umezawa, R., Ito, Y., Itami, J., Koyanagi, K., Igaki, H., & Tachimori, Y. (2017). Clinical outcomes of resectable esophageal cancer with supraclavicular lymph node metastases treated with curative intent. Anticancer research, 37(7), 3741-3749. https://doi.org/10.21873/anticanreS.11748