Clinical characteristics of young-onset and medical treatment-requiring hypertension identified by targeted screening in university health check-up

Yasuhiro Endo, Fukashi Serizawa, Takumi Kato, Hiroaki Toyama, Yutaka Ejima, Akira Sato, Shin Kurosawa, Yoko Hasegawa, Wataru Hida, Mitsunobu Matsubara

研究成果: Article査読

抄録

Based on targeted screening for hypertension at a university health check-up, we previously reported a high incidence of white-coat hypertension and estimated prevalence of hypertension requiring medical treatments (HT) as around 0.1% in young population aged less than 30. In spite of such low prevalence, continuous screening for seven consecutive years (20032009) increased the number of HT students to 20 (19 males and 1 female). We presently assessed the clinical characteristics of these HTs. Renovascular hypertension was found in the only female HT and aortic valve regurgitation in two HTs. Resting 17 HTs were diagnosed as having essential hypertension (EH). A father and/or a mother had EH in 16 out of 17 EHs, and blood pressure (BP) at home was slightly elevated (135145 mm Hg in systolic) except three obese EHs (body mass index more than 30) who demonstrated more than 160 mm Hg in systolic. Plasma aldosterone-renin ratio (ARR) of EHs did not differ from that of normal controls, and Pearson correlation coefficient (R) between ARR and systolic BP (SBP) was -0.2. Its partial correlation coefficient, however, was statistically significant (R = -0.55, P = .026) after correcting for body mass index, which was significantly correlated with both SBP (P = .006, after correcting for ARR) and ARR (P = .004, after correcting for SBP). In conclusion, most of young-onset HTs are male EHs, and aortic valve regurgitation should be carefully checked. Excess plasma renin activity would be one of additional characteristics of young-onset EH to male gender, genetic background, and increased body mass.

本文言語English
ページ(範囲)552-557
ページ数6
ジャーナルClinical and Experimental Hypertension
33
8
DOI
出版ステータスPublished - 2011 12

ASJC Scopus subject areas

  • 内科学
  • 生理学

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