Clinical characteristics of idiopathic normal pressure hydrocephalus with Lewy body diseases

Hayato Odagiri, Toru Baba, Yoshiyuki Nishio, Osamu Iizuka, Wataru Narita, Minoru Matsuda, Etsuro Mori

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Background Comorbidity of idiopathic normal pressure hydrocephalus and neurodegenerative diseases presents a diagnostic challenge. The aim of this study was to elucidate the clinical features of iNPH patients who are possibly comorbid with Lewy body diseases. Methods In this study, we retrospectively analyzed the records of consecutive 127 patients with definite idiopathic normal pressure hydrocephalus. 123I-Metaiodobenzylguanidine myocardial scintigraphy was undertaken to 21 patients with idiopathic normal pressure hydrocephalus because of suspicion for comorbid Lewy body diseases. Results As a result, 7 of the 21 patients with idiopathic normal pressure hydrocephalus exhibited cardiac sympathetic abnormality. Idiopathic normal pressure hydrocephalus patients with cardiac sympathetic dysfunction had the constellation of clinical findings, such as younger onset, less severe urinary dysfunction, kinesie paradoxale, and cogwheel rigidity. Conclusions Our results suggested that comorbidity of idiopathic normal pressure hydrocephalus and Lewy body diseases are not rare condition and careful screening for potentially-curative surgery is important especially in atypical cases.

本文言語English
ページ(範囲)309-311
ページ数3
ジャーナルJournal of the neurological sciences
359
1-2
DOI
出版ステータスPublished - 2015 12 15

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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