Clinical characteristics and prognostic factors in elderly patients with chronic heart failure -A report from the CHART-2 study-

Masayuki Sato, Yasuhiko Sakata, Kenjiro Sato, Kotaro Nochioka, Masanobu Miura, Ruri Abe, Takuya Oikawa, Shintaro Kasahara, Hajime Aoyanagi, Shinsuke Yamanaka, Takahide Fujihashi, Hideka Hayashi, Takashi Shiroto, Koichiro Sugimura, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Background: Since most of the randomized clinical trials for heart failure (HF) were designed to exclude elderly patients, limited data are available on their clinical characteristics, prognosis, and prognostic factors. Methods: We compared clinical characteristics, prognosis, and prognostic factors among Stage C/D HF patients in our CHART-2 Study (N = 4876, mean 69 years, women 32%, 6.3-year follow-up) by age (G1, ≤64 years, N = 1521; G2, 65–74 years, N = 1510; and G3, ≥75 years, N = 1845). Results: From G1 to G3, the prevalence of women, left ventricular ejection fraction (LVEF) and plasma levels of B-type natriuretic peptide (BNP) increased (all P < 0.001). Similarly, 5-year mortality increased (9.9, 17.3 to 39.9%, P < 0.001) along with a decrease in proportion of cardiovascular death and an increase in non-cardiovascular death in both sexes. While all-cause and cardiovascular mortality was comparable between the sexes, women had significantly lower incidence of non-cardiovascular death than men in G2 and G3, which was attributable to the higher incidence of cancer death and pneumonia death in men than in women. Although NYHA functional class III-IV, chronic kidney disease, cancer, LVEF, and BNP had significant impacts on all-cause death in all groups, their impacts were less evident in G3 as compared with G1. Conclusions: The elderly HF patients, as compared with younger HF patients, were characterized by more severe clinical background, increased proportion of non-cardiovascular death and worse prognosis with different impacts of prognostic factors across the age groups.

本文言語English
論文番号100497
ジャーナルIJC Heart and Vasculature
27
DOI
出版ステータスPublished - 2020 4

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

フィンガープリント 「Clinical characteristics and prognostic factors in elderly patients with chronic heart failure -A report from the CHART-2 study-」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル