Clinical and electrocardiographic differences in brugadsyndrome with spontaneous or drug-induced type 1 electrocardiogram

Tomomi Nagayama, Satoshi Nagase, Tsukasa Kamakura, Mitsuru Wada, Kohei Ishibashi, Yuko Y. Inoue, Koji Miyamoto, Takashi Noda, Takeshi Aiba, Hiroshi Takaki, Masaru Sugimachi, Wataru Shimizu, Teruo Noguchi, Satoshi Yasuda, Shiro Kamakura, Kengo Kusano

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Background: Spontaneous type 1 electrocardiogram (ECG) in the right precordial lead is a dominant predictor of ventricular fibrillation (VF) in Brugada syndrome (BrS). In some BrS patients with VF, however, spontaneous type 1 ECG is undetectable, even in repeated ECG and immediately after VF. This study investigated differences between BrS patients with spontaneous or drug-induced type 1 ECG. Methods and Results: We evaluated 15 BrS patients with drug-induced (D-BrS) and 29 with spontaneous type 1 ECG (SP-BrS). All patients had had a previous VF episode. In each D-BrS patient, ECG was recorded more than 15 times (mean, 46±34) during 7.2±5.1 years of follow-up. Age and family history were comparable between groups. Inferolateral early repolarization (ER) was observed in 13 D-BrS (87%) at least once but in only 3 SP-BrS (10%, P<0.01). Immediately after VF, inferolateral ER was accentuated in 9 of 10 D-BrS, while type 1 ECG was accentuated in 12 of 16 SP-BrS. Fragmented QRS in the right precordial lead and aVR sign were absent in D-BrS but present in 20 (69%, P<0.01) and 11 (38%, P<0.01) SP-BrS, respectively. There was no prognostic difference between groups. Conclusions: Although having similar clinical profiles, there are obvious ECG differences between VF-positive BrS patients with spontaneous or drug-induced type 1 ECG. The inferolateral lead rather than the right precordial lead on ECG may be particularly crucial in some BrS patients.

本文言語English
ページ(範囲)532-539
ページ数8
ジャーナルCirculation Journal
83
3
DOI
出版ステータスPublished - 2019 2月 25
外部発表はい

ASJC Scopus subject areas

  • 循環器および心血管医学

フィンガープリント

「Clinical and electrocardiographic differences in brugadsyndrome with spontaneous or drug-induced type 1 electrocardiogram」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル