Click-based synthesis and proteomic profiling of lipstatin analogues

Mun H. Ngai, Peng Yu Yang, Kai Liu, Yuan Shen, Markus R. Wenk, Shao Q. Yao, Martin J. Lear

研究成果: Article査読

41 被引用数 (Scopus)

抄録

Using click chemistry to enable both structural diversity and proteome profiling within a natural product derived library, two out of nineteen lipstatin analogues showed similar activity to Orlistat against fatty acid synthase (FAS), but with an improved ability to induce tumour cell death.

本文言語English
ページ(範囲)8335-8337
ページ数3
ジャーナルChemical Communications
46
44
DOI
出版ステータスPublished - 2010 11 28

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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