TY - JOUR
T1 - Chronic Active Antibody-Mediated Rejection With Donor-Specific Anti–HLA-DP Antibodies Following Living Donor Kidney Transplantation
T2 - A Case Report
AU - Fukuoka, Kengo
AU - Tokodai, Kazuaki
AU - Miyagi, Shigehito
AU - Nakanishi, Wataru
AU - Nishimura, Ryuichi
AU - Fujio, Atsushi
AU - Watanabe, Hirofumi
AU - Taniuchi, Shinji
AU - Naito, Takeshi
AU - Ishida, Takanori
AU - Unno, Michiaki
AU - Kamei, Takashi
N1 - Funding Information:
This study was supported by JSPS KAKENHI (grant No. JP17K16502 ).
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Posttransplant donor-specific anti-HLA antibodies (DSA) cause chronic antibody-mediated rejection. Anti-DR and anti-DQ DSAs have especially been shown to be associated with negative graft function. In contrast, the prevalence and significance of anti-DP DSA have not been well established and remain unclear. We report a case of living donor kidney transplantation. The level of serum creatinine gradually became elevated because of chronic active antibody-mediated rejection, which was considered to be caused by anti-DP DSA. In this report, we indicate the significance of pretransplant screening for HLA-DP in donors to evaluate more comprehensively the donor specificity of posttransplant HLA antibodies.
AB - Posttransplant donor-specific anti-HLA antibodies (DSA) cause chronic antibody-mediated rejection. Anti-DR and anti-DQ DSAs have especially been shown to be associated with negative graft function. In contrast, the prevalence and significance of anti-DP DSA have not been well established and remain unclear. We report a case of living donor kidney transplantation. The level of serum creatinine gradually became elevated because of chronic active antibody-mediated rejection, which was considered to be caused by anti-DP DSA. In this report, we indicate the significance of pretransplant screening for HLA-DP in donors to evaluate more comprehensively the donor specificity of posttransplant HLA antibodies.
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U2 - 10.1016/j.transproceed.2020.02.130
DO - 10.1016/j.transproceed.2020.02.130
M3 - Article
C2 - 32586663
AN - SCOPUS:85086730284
SN - 0041-1345
VL - 52
SP - 1937
EP - 1939
JO - Transplantation Proceedings
JF - Transplantation Proceedings
IS - 6
ER -