Chromatography-free Pd-catalyzed deprotection of allyl ethers using PS-DEAM as a scavenger of boronic acids and Pd catalyst

Hirokazu Tsukamoto, Takamichi Suzuki, Masanori Sato, Yoshinori Kondo

研究成果: Article査読

9 被引用数 (Scopus)

抄録

Polystyrene-bound diethanolamine (PS-DEAM) work-up for a newly developed Pd(PPh3)4-catalyzed cleavage of allylic alkyl ethers using phenylboronic acid can effectively release Pd-free parent alcohols. Furthermore, chromatography-free deallylation can be conducted by using vinylboronic anhydride pyridine complex as an allyl scavenger with a catalytic amount of Pd(OAc)2 and 4-(diphenylphosphino)benzoic acid instead of Pd(PPh3)4 to yield the desired products in high purities and yields after removal of volatile byproducts and the phosphine-derived contaminants by evaporation and sequestration through acid-base interaction with PS-DEAM, respectively.

本文言語English
ページ(範囲)8438-8441
ページ数4
ジャーナルTetrahedron Letters
48
48
DOI
出版ステータスPublished - 2007 11 26

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

フィンガープリント 「Chromatography-free Pd-catalyzed deprotection of allyl ethers using PS-DEAM as a scavenger of boronic acids and Pd catalyst」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル