Chloride imbalance is involved in the pathogenesis of optic neuritis in neuromyelitis optica

Tetsuya Akaishi, Toshiyuki Takahashi, Noriko Himori, Takayuki Takeshita, Toru Nakazawa, Masashi Aoki, Ichiro Nakashima

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Chloride imbalance between the serum and the cerebrospinal fluid (CSF) has been recently shown to exist in the acute phase of neuromyelitis optica (NMO). In this report, we studied the relation between the quotient of chloride (QCl) and the severity of optic neuritis (ON) in NMO patients. There was a positive correlation (R = 0.67; p < 0.05) between QCl and the length of ON-lesion. The visual prognosis also showed a positive correlation with QCl in the acute phase (R = 0.58; p < 0.05). These results support the theory that chloride imbalance between serum and CSF may trigger the ON in NMO spectrum disorders.

本文言語English
ページ(範囲)98-100
ページ数3
ジャーナルJournal of Neuroimmunology
320
DOI
出版ステータスPublished - 2018 7 15

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学
  • 神経学
  • 臨床神経学

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