Chiral Selective Adsorption of Ibuprofen on a Liposome Membrane

Yukihiro Okamoto, Yusuke Kishi, Takaaki Ishigami, Keishi Suga, Hiroshi Umakoshi

研究成果: Article査読

27 被引用数 (Scopus)

抄録

We investigated the key factors that affect enantioselective adsorption of ibuprofen (IBU) on a liposome membrane by changing its lipid composition: the liposome membrane shows different membrane fluidity, surface charge, content of chiral components, and heterogeneity (nanodomain). Nonspecific interactions (hydrophobic and electrostatic) were revealed to be an important factor in enhancing the adsorbed amount of IBU, based on adsorption experiments carried out using single lipids (DPPC, DMPC, DOPC, and DLPC) and positively charged liposomes (DOTAP and liposome containing DC-Ch). Furthermore, control of the boundary edge (i.e., the nanodomain size) derived from the membrane heterogeneity was important for enantioselective adsorption; as well as multiple weak interactions between lipid molecules and IBU enantiomers. The above findings provided a good index for constructing liposomal chiral adsorbents.

本文言語English
ページ(範囲)2790-2795
ページ数6
ジャーナルJournal of Physical Chemistry B
120
10
DOI
出版ステータスPublished - 2016 3 17
外部発表はい

ASJC Scopus subject areas

  • 物理化学および理論化学
  • 表面、皮膜および薄膜
  • 材料化学

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