Chiral Recognition of l -Amino Acids on Liposomes Prepared with l -Phospholipid

Takaaki Ishigami, Keishi Suga, Hiroshi Umakoshi

研究成果: Article査読

53 被引用数 (Scopus)

抄録

In this study, we demonstrated that liposomes composed of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) can recognize several l-amino acids, but not their d-enantiomers, by analyzing their adsorptive behavior and using circular dichroism spectroscopy. Changes in liposomal membrane properties, determined based on fluorescent probe analysis and differential scanning calorimetry, were induced by l-amino acid binding. UV resonance Raman spectroscopy analysis suggested that the chiral recognition was mediated by electrostatic, hydrophobic, and hydrogen bond interactions, where the recognition site could therefore be constructed on the DPPC membrane. Our findings clearly indicate the potential function of liposomes in asymmetric recognition.

本文言語English
ページ(範囲)21065-21072
ページ数8
ジャーナルACS Applied Materials and Interfaces
7
38
DOI
出版ステータスPublished - 2015 9 30
外部発表はい

ASJC Scopus subject areas

  • 材料科学(全般)

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