Chiral bisphosphazides as dual basic enantioselective catalysts

Hiroshi Naka, Nobuhiko Kanase, Masahiro Ueno, Yoshinori Kondo

研究成果: Article

29 引用 (Scopus)

抜粋

Chiral bisphosphazides complexed with lithium salts efficiently catalyze the direct enantioselective 1,4-addition of dialkyl malonates to acyclic enones. Spectroscopic studies on the stoichiometry of the bisphosphazide and lithium salt have indicated the formation of a 1:1 species as the active enantioselective catalyst. It is suggested that the catalyst generates a complex of the protonated phosphazide and the chiral nucleophile as the key intermediate. The phosphazide moiety appears to be a promising dual basic functionality for stereo- and chemoselective catalytic transformations.

元の言語English
ページ(範囲)5267-5274
ページ数8
ジャーナルChemistry - A European Journal
14
発行部数17
DOI
出版物ステータスPublished - 2008 6 9

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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