Chemokine receptor expression on T cells in blood and cerebrospinal fluid at relapse and remission of multiple sclerosis: Imbalance of Th1/Th2-associated chemokine signaling

Tatsuro Misu, Hiroshi Onodera, Kazuo Fujihara, Koji Matsushima, Osamu Yoshie, Naoshi Okita, Sadao Takase, Yasuto Itoyama

研究成果: Article査読

118 被引用数 (Scopus)

抄録

The expression of chemokine receptors on lymphocytes in the blood and CSF of multiple sclerosis (MS) patients was analyzed at relapse and remission. Both CD4+ and CD8+ cells in CSF at relapse were enriched for Th1-type receptors CXCR3 and CCR5 expression, and were reduced for Th2-type receptors CCR3 and CCR4 expression compared with those of the blood. CCR1 and CCR2 expressions on T cells were increased in CSF and blood, respectively. At remission, CCR5 expression, but not CXCR3 expression, was reduced in CSF CD4+ cells. A biased Th1/Th2 balance may play a critical role in active inflammation and CCR5 on CSF CD4+ cells is a good marker of the disease activity.

本文言語English
ページ(範囲)207-212
ページ数6
ジャーナルJournal of Neuroimmunology
114
1-2
DOI
出版ステータスPublished - 2001 3 1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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