Chemical and etiological studies on tetrodotoxin and its analogs

Takeshi Yasumoto, Mari Yamashita

研究成果: Review article査読

75 被引用数 (Scopus)

抄録

The marked fluctuation of tetrodotoxin (TTX) contents in pufferfish led us to suspect the exogenous origin of the toxin. Based on a food chain hypothesis, various marine biota were tested for TTX with a fluorometric tetrodotoxin analyzer. Consequently, bacteria were found to be the genetic origin of TT. The survey also revealed the occurrence of new TTX analogs in pufferfish, newts and a frog. Those analogs were isolated and their chemical structures were determined. The analogs provided valuable information on biosynthetic as well as metabolic pathways of TTX and on structure-activity relationship.

本文言語English
ページ(範囲)81-90
ページ数10
ジャーナルJournal of Toxicology - Toxin Reviews
15
2
DOI
出版ステータスPublished - 1996 1 1

ASJC Scopus subject areas

  • 毒物学
  • 健康、毒物学および変異誘発

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