Characterization of variant creutzfeldt-jakob disease prions in prion protein-humanized mice carrying distinct codon 129 genotypes

Atsuko Takeuchi, Atsushi Kobayashi, James W. Ironside, Shirou Mohri, Tetsuyuki Kitamoto

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Background: Secondary vCJD infection may occur in all human PRNP genotypes, but its clinicopathological and biochemical phenotype is uncertain. Results: The biochemical characteristics and transmission properties of the newly generated vCJD prions are not affected by the host PRNP genotypes. Conclusion: Secondary vCJD infection can be adequately diagnosed by biochemical analysis and experimental transmission. Significance: Effective means to identify secondary vCJD infection are presented.

本文言語English
ページ(範囲)21659-21666
ページ数8
ジャーナルJournal of Biological Chemistry
288
30
DOI
出版ステータスPublished - 2013 7 26

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

フィンガープリント 「Characterization of variant creutzfeldt-jakob disease prions in prion protein-humanized mice carrying distinct codon 129 genotypes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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