Characterization of variant creutzfeldt-jakob disease prions in prion protein-humanized mice carrying distinct codon 129 genotypes

Atsuko Takeuchi; Atsushi Kobayashi; James W. Ironside; Shirou Mohri; Tetsuyuki Kitamoto

doi:10.1074/jbc.M113.470328

Characterization of variant creutzfeldt-jakob disease prions in prion protein-humanized mice carrying distinct codon 129 genotypes

Atsuko Takeuchi, Atsushi Kobayashi, James W. Ironside, Shirou Mohri, Tetsuyuki Kitamoto

医学系研究科・附属創成応用医学研究センター

研究成果: Article › 査読

12 被引用数 (Scopus)

抄録

Background: Secondary vCJD infection may occur in all human PRNP genotypes, but its clinicopathological and biochemical phenotype is uncertain. Results: The biochemical characteristics and transmission properties of the newly generated vCJD prions are not affected by the host PRNP genotypes. Conclusion: Secondary vCJD infection can be adequately diagnosed by biochemical analysis and experimental transmission. Significance: Effective means to identify secondary vCJD infection are presented.

本文言語	English
ページ（範囲）	21659-21666
ページ数	8
ジャーナル	Journal of Biological Chemistry
巻	288
号	30
DOI	https://doi.org/10.1074/jbc.M113.470328
出版ステータス	Published - 2013 7 26

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

文献へのアクセス

10.1074/jbc.M113.470328

フィンガープリント「Characterization of variant creutzfeldt-jakob disease prions in prion protein-humanized mice carrying distinct codon 129 genotypes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

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AU - Ironside, James W.

AU - Mohri, Shirou

AU - Kitamoto, Tetsuyuki

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AB - Background: Secondary vCJD infection may occur in all human PRNP genotypes, but its clinicopathological and biochemical phenotype is uncertain. Results: The biochemical characteristics and transmission properties of the newly generated vCJD prions are not affected by the host PRNP genotypes. Conclusion: Secondary vCJD infection can be adequately diagnosed by biochemical analysis and experimental transmission. Significance: Effective means to identify secondary vCJD infection are presented.

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