Characterization of the immunomodulatory and anti-Helicobacter pylori properties of the human gastric isolate Lactobacillus rhamnosus UCO-25A

Valeria Garcia-Castillo, Ana María Marín-Vega, Alejandra Ilabaca, Leonardo Albarracín, Guillermo Marcial, Haruki Kitazawa, Apolinaria Garcia-Cancino, Julio Villena

研究成果: Article査読

5 被引用数 (Scopus)

抄録

The ability to form biofilms and the potential immunomodulatory properties of the human gastric isolate Lactobacillus rhamnosus UCO-25A were characterized in vitro. It was demonstrated that L. rhamnosus UCO-25A is able to form biofilms on abiotic and cell surfaces, and to modulate the inflammatory response triggered by Helicobacter pylori infection in gastric epithelial cells and THP-1 macrophages. L. rhamnosus UCO-25A exhibited a substantial anti-inflammatory effect in both cell lines and improved IL-10 levels produced by challenged macrophages. Additionally, UCO-25A protected AGS cells against H. pylori infection with a higher pathogen inhibition when a biofilm was formed. Given the importance of inflammation in H. pylori-mediated diseases, the differential modulation of the inflammatory response in the gastric mucosa by an autochthonous strain is an attractive alternative for improving H. pylori eradication and reducing the severity of the diseases that arise from the resulting chronic inflammation.

本文言語English
ページ(範囲)922-937
ページ数16
ジャーナルBiofouling
35
8
DOI
出版ステータスPublished - 2019 9 14

ASJC Scopus subject areas

  • 水圏科学
  • 応用微生物学とバイオテクノロジー
  • 水の科学と技術

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