Recently, the research on the stem cells is developing rapidly in the odontology. Mesenchymal stem cells (MSCs) have the possibility useful for the stem cell treatment and the tissue engineering. STRO-1 is one of the mesenchymal stem cell markers. In this study, we examined the characterization of STRO-1 posi- tive cells derived from human wisdom tooth germs (hWTGs) compared with STRO-1 negative cells. As positive control, we used human mesenchymal stem cells (HMSC) on purchase. STRO-1 positive cells derived from hWTGs showed Alcian blue positive matrix like HMSC when cultured in chondrogenic induction medium. STRO-1 negative cells from hWTGs did not show such matrix. Nodule formation stained with Alizarin red was performed not only by STRO-1 positive cells but also STRO-1 negative cells cultured in osteogenic induction medium. It is suggested that STRO-1 positive cells derived from hWTGs are useful for the stem cell treatment and the tissue engineering.
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