Characterization of middle-molecule introduction into cells using mm-scale discharge in saline

研究成果: Article査読

2 被引用数 (Scopus)

抄録

While gas-phase atmospheric pressure plasma (APP) is a promising technology for highly-efficient and minimally-invasive gene/drug (molecule) introduction, the reduction of external gas supply and the expansion of the effective treatment area in biological fluids for in vivo treatment are still challenging. We developed a device for mm-scale plasma generation in saline without working gas supply and demonstrated the local introduction of YOYO-1 molecule (molecular weight : 1271) into cultured cells using the device. Unlike the conventional APP accounting for chemical stimuli with reactive species, plasma-induced mechanical stimulus was indicated as one of key factor(s) in the molecule introduction.

本文言語English
論文番号040904
ジャーナルJapanese journal of applied physics
59
4
DOI
出版ステータスPublished - 2020 4 1

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

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