Characterization of a titanium(IV)-porphyrin complex as a highly sensitive and selective reagent for the determination of hydrogen peroxide: A computational chemistry approach and a critical review

Kiyoko Takamura, Takatoshi Matsumoto

研究成果: Article査読

15 被引用数 (Scopus)

抄録

The Ti-TPyP reagent, i.e. an acidic aqueous solution of the oxo[5,10,15,20-tetra(4-pyridyl)porphyrinato] titanium(IV) complex, TiO(tpyp), was developed as a highly sensitive and selective spectrophotometric reagent for determination of traces of hydrogen peroxide. Using this reagent, determination of hydrogen peroxide was performed by flow-injection analysis with a detection limit of 0.5 pmol per test. The method was actually applied to determination of several constituents of foods, human blood, and urine mediated by appropriate oxidase enzymes. The reaction specificity of the TiO(tpyp) complex for hydrogen peroxide was clarified from the viewpoint of the reaction mechanisms and molecular orbitals based on ab initio calculations. The results provided a well-grounded argument for determination of hydrogen peroxide using the Ti-TPyP reagent experimentally. This review deals with characterization of the high sensitivity and reaction specificity of the Ti-TPyP reagent for determination of hydrogen peroxide, to prove its reliability in analytical applications.

本文言語English
ページ(範囲)951-961
ページ数11
ジャーナルAnalytical and Bioanalytical Chemistry
391
3
DOI
出版ステータスPublished - 2008 6月 1

ASJC Scopus subject areas

  • 分析化学
  • 生化学

フィンガープリント

「Characterization of a titanium(IV)-porphyrin complex as a highly sensitive and selective reagent for the determination of hydrogen peroxide: A computational chemistry approach and a critical review」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル