Characteristics of the increase in plasma brain natriuretic peptide level in left ventricular systolic dysfunction, associated with muscular dystrophy in comparison with idiopathic dilated cardiomyopathy

Jun Demachi, Yutaka Kagaya, Jun Watanabe, Masahito Sakuma, Jun Ikeda, Yasunori Kakuta, Iyoko Motoyoshi, Takeshi Kohnosu, Hiroaki Sakuma, Shigeru Shimazaki, Hideaki Sakai, Teiko Kimpara, Toshiaki Takahashi, Kiyoshi Omura, Miho Okada, Hiroshi Saito, Kunio Shirato

研究成果: Article査読

21 被引用数 (Scopus)

抄録

To determine whether the plasma brain natriuretic peptide level increases differentially in muscular dystrophy and idiopathic dilated cardiomyopathy, we investigated the plasma brain natriuretic peptide level and echocardiographic parameters in patients with similarly low left ventricular ejection fraction. The plasma brain natriuretic peptide level was lower, and the left ventricular end-diastolic diameter was shorter in the patients with muscular dystrophy than in those with idiopathic dilated cardiomyopathy. The correlation between the plasma brain natriuretic peptide and left ventricular ejection fraction was shifted downward in the patients with muscular dystrophy compared with those with idiopathic dilated cardiomyopathy. Those between the brain natriuretic peptide and left ventricular end-diastolic diameter were superimposable, although the data from the muscular dystrophy patients were located at the shorter left ventricular end-diastolic diameter side. The plasma brain natriuretic peptide level may differentially increase in the two diseases with similar left ventricular systolic dysfunction. Differences in the left ventricular distension and in the physical activity might explain at least partially the different plasma brain natriuretic peptide levels.

本文言語English
ページ(範囲)732-739
ページ数8
ジャーナルNeuromuscular Disorders
14
11
DOI
出版ステータスPublished - 2004 11

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Clinical Neurology
  • Genetics(clinical)

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