Characteristic findings of skeletal muscle MRI in caveolinopathies

Kumiko Ishiguro, Takahiro Nakayama, Masaru Yoshioka, Terumi Murakami, Sachiko Kajino, Minobu Shichiji, Takatoshi Sato, Naomi Hino-Fukuyo, Satoshi Kuru, Makiko Osawa, Satoru Nagata, Mariko Okubo, Nobuyuki Murakami, Yukiko K. Hayashi, Ichizo Nishino, Keiko Ishigaki

研究成果: Article査読

6 被引用数 (Scopus)


Caveolinopathies, caused by CAV3 mutations, can include several phenotypes such as rippling muscle disease, limb-girdle muscular dystrophy type 1C, distal myopathy, familial hypertrophic cardiomyopathy, and idiopathic hyperCKemia. Here we present characteristic skeletal muscle imaging findings in four patients with genetically defined childhood-onset RMD caused by CAV3 mutations and in one patient with congenital generalized lipodystrophy type 4 with muscular dystrophy due to polymerase I and transcript release factor (PTRF) mutations, which may have caused secondary deficiency of caveolin-3. Muscle MRI revealed that the rectus femoris and semitendinosus muscles were most commonly affected in the rippling muscle disease patients. Peripheral changes in the rectus femoris were specific and observed even in one of the younger patients in this study. Furthermore, muscle involvement extended to the semitendinosus muscles, biceps femoris, and gracilis with disease progression or increase in its severity. Similar patterns of involvement were observed on reviewing skeletal muscle images of various previously reported phenotypes of caveolinopathy; interestingly, patients with secondary deficiency of caveolin due to PTRF mutations revealed the same pattern. Thus, primary caveolinopathies and secondary deficiency of caveolin demonstrated specific findings on skeletal muscle imaging, regardless of the broad phenotypic spectrum of these two conditions.

ジャーナルNeuromuscular Disorders
出版ステータスPublished - 2018 10月

ASJC Scopus subject areas

  • 小児科学、周産期医学および子どもの健康
  • 神経学
  • 臨床神経学
  • 遺伝学(臨床)


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