Chapter 12: Molecular and cellular studies on brain calcium/calmodulin-dependent protein kinase II

T. R. Soderling, K. Fukunaga, D. A. Brickey, Y. L. Fong, D. P. Rich, K. Smith, R. J. Colbran

研究成果: Article査読

10 被引用数 (Scopus)

抄録

This chapter discusses brain CaM-kinase II with a particular focus on its unique regulatory properties, its regulation in cultured brain cells, and its physiological functions. CaM-kinase II has widespread tissue distribution as oligomeric isozyme forms and is particularly abundant in the brain. In certain regions of the brain, such as hippocampus, it constitutes up to 2% of total protein, which probably makes it the most abundant enzyme in these tissues. CaM-kinase II is localized presynaptically where it is involved in Ca2+-dependent regulation of neurotransmitter biosynthesis and exocytosis. At excitatory synapses in forebrain, there is a thickening of the postsynaptic membrane called the postsynaptic density (PSD), and CaM-kinase II constitutes about 30–50% of the protein in the PSD. These excitatory synapses are subject to a usage-dependent enhancement of synaptic transmission called long-term potentiation (LTP)—a popular model for learning and memory.

本文言語English
ページ(範囲)169-183
ページ数15
ジャーナルProgress in Brain Research
89
C
DOI
出版ステータスPublished - 1991 1 1
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

フィンガープリント

「Chapter 12: Molecular and cellular studies on brain calcium/calmodulin-dependent protein kinase II」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル