We investigated the susceptibity to quinolones and other antimicrobacterial agents of 1,697 Staphylococcus aureus clinical isolates from the Tohoku district collected over the last eight years. The incidence of methicillin-resistant Staphylococcus aureus (MRSA) rose from 25.5% to 49.1% during the eight years. During the above period, susceptibity to ofloxacin remained at almost the same level for methicillin-susceptible Staphylococcus aureus (MSSA). On the other hand MRSA became more resistant year by year, and the MIC90 of ofloxacin against MRSA rose from 0.78 μg/ml in 1986 to 64 μg/ml in 1993. This tendency was observed very frequently among isolates from all institutions and specimens, irrespective of whether they were from in- or out-patients. In was also found that these isolates were generally resistant to quinolones other than ofloxacin.
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