In order to elucidate the mechanism of intestinal adaptation, an experimental study was performed in dogs with ileojejunal transposition (IJT) and sham operation. Glucose tolerance was transiently deteriorated in a course after the operation in the IJT group. During oral glucose load, the IJT group revealed an exaggerated response of plasma total glucagon (IRG), measured with a nonspecific antiserum, at 4 weeks and later. A 12 weeks no abnormalities were observed in liver function, renal function, and serum protein or lipids in the IJT group. However, the IJT group revealed a decrease in plasma total amino acids and a marked reduction in several of them. At autopsy the intestine was markedly thickened in the IJT group. GLI content of the mucosal layer of the small intestine, extracted by the method of Kenny, increased ten-fold in the IJT group. Column chromatography elicited a main peak at the glicentin marker for plasma and gut GLI. There was a significant correlation between the glucagon content in the ileum and plasma response of total IRG to oral glucose load. The present study indicates that gut GLI (glicentin) plays an important role in the etiology of intestinal adaptation.
|出版ステータス||Published - 1988 1 1|
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