Changes in Ca2+/calmodulin-dependent protein kinase II activity and its relation to performance in passive avoidance response and long-term potentiation formation in mice prenatally exposed to diethylstilbestrol

T. Kaitsuka, K. Fukunaga, F. Soeda, T. Shirasaki, E. Miyamoto, K. Takahama

研究成果: Article査読

16 被引用数 (Scopus)

抄録

We investigated the effects of prenatal exposure to diethylstilbestrol (DES), an endocrine disrupter on learning behavior and synaptic functions. Specifically, we determined the activity of Ca2+/calmodulin-dependent protein kinase II (CaMKII) and related kinases that play an essential role in long-term potentiation (LTP) in the hippocampus in mice that were prenatally exposed to DES. Treatment with DES resulted in increased CaMKII autophosphorylation and Ca2+-independent activity in the hippocampus and cortex of male mice. Impaired passive avoidance correlated with this increased CaMKII autophosphorylation, as did the enhanced early phase of LTP (E-LTP) in hippocampus. These data suggest that prenatal exposure to DES induces deficits in passive avoidance responses as a result of increased CaMKII activity and hippocampal LTP.

本文言語English
ページ(範囲)1415-1424
ページ数10
ジャーナルNeuroscience
144
4
DOI
出版ステータスPublished - 2007 2 23

ASJC Scopus subject areas

  • 神経科学(全般)

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