TY - JOUR
T1 - Change in Relative Mobility of M Protein Following Neuraminidase Treatment in Patients with Multiple Myeloma and Monoclonal Gammopathy of Undetermined Significance
AU - Kurihara, Yuriko
AU - Iijima, Shiro
AU - Fukushima, Kouhei
AU - Hosaka, Toshiaki
AU - Shiba, Kiyoko
PY - 2004
Y1 - 2004
N2 - The aim of this study was to clarify the relationship between the relative mobility of M protein in various disease states using cellulose acetate membrane electrophoresis. To examine the carbohydrate chain of the M protein, sera from patients with multiple myeloma (MM), various cancers, and benign disease were treated with neuraminidase. The relative mobility in benign disease and MM patient sera following neuraminidase treatment varied among individuals, while that of IgG M protein in sera from cancer patients was from 0.2 to 0.3. Thus, the relative mobility in cancer patients was narrower than in those with MM or benign disease. However, after neuraminidase treatment, there was no significant difference between relative mobility in cancer patient's sera and those in other disease patients.
AB - The aim of this study was to clarify the relationship between the relative mobility of M protein in various disease states using cellulose acetate membrane electrophoresis. To examine the carbohydrate chain of the M protein, sera from patients with multiple myeloma (MM), various cancers, and benign disease were treated with neuraminidase. The relative mobility in benign disease and MM patient sera following neuraminidase treatment varied among individuals, while that of IgG M protein in sera from cancer patients was from 0.2 to 0.3. Thus, the relative mobility in cancer patients was narrower than in those with MM or benign disease. However, after neuraminidase treatment, there was no significant difference between relative mobility in cancer patient's sera and those in other disease patients.
KW - Cellulose acetate membrane electrophoresis
KW - M protein
KW - Neuraminidase treatment
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U2 - 10.1002/jcla.20020
DO - 10.1002/jcla.20020
M3 - Article
C2 - 15103683
AN - SCOPUS:2342584762
VL - 18
SP - 182
EP - 186
JO - Journal of Clinical Laboratory Analysis
JF - Journal of Clinical Laboratory Analysis
SN - 0887-8013
IS - 3
ER -