Change in Relative Mobility of M Protein Following Neuraminidase Treatment in Patients with Multiple Myeloma and Monoclonal Gammopathy of Undetermined Significance

Yuriko Kurihara, Shiro Iijima, Kouhei Fukushima, Toshiaki Hosaka, Kiyoko Shiba

研究成果: Article査読

抄録

The aim of this study was to clarify the relationship between the relative mobility of M protein in various disease states using cellulose acetate membrane electrophoresis. To examine the carbohydrate chain of the M protein, sera from patients with multiple myeloma (MM), various cancers, and benign disease were treated with neuraminidase. The relative mobility in benign disease and MM patient sera following neuraminidase treatment varied among individuals, while that of IgG M protein in sera from cancer patients was from 0.2 to 0.3. Thus, the relative mobility in cancer patients was narrower than in those with MM or benign disease. However, after neuraminidase treatment, there was no significant difference between relative mobility in cancer patient's sera and those in other disease patients.

本文言語English
ページ(範囲)182-186
ページ数5
ジャーナルJournal of Clinical Laboratory Analysis
18
3
DOI
出版ステータスPublished - 2004
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 血液学
  • 公衆衛生学、環境および労働衛生
  • 臨床生化学
  • 医療検査技術
  • 生化学、医学
  • 微生物学(医療)

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