Cellular colocalization of calcium/calmodulin-dependent protein kinase II and calcineurin in the rat cerebral cortex and hippocampus

Satoshi Goto, Shinji Nagahiro, Kojiro Korematsu, Yukitaka Ushio, Kohji Fukunaga, Eishichi Miyamoto, Walter Hofer

研究成果: Article査読

22 被引用数 (Scopus)

抄録

An immunoperoxidase technique was used to locate multifunctional Ca2+/calmodulin-regulated protein phosphatase (calcineurin) and kinase (CaM-kinase II) in the rat cerebral cortex and hippocampus. Immunoreactivities for both enzymes were highly concentrated in the brain regions, where pyramidal-shaped neurons revealed strong immunoreactivities in their perikarya and dendrites. Serial thin section analysis using the polyethylene glycol embedding procedure disclosed that the cellular distribution of calcineurin immunolabelling in the cerebral cortex and hippocampus was similar to that of CaM-kinase II. The present findings suggest that the phosphatase and kinase may interact with each other in such neuronal subsets.

本文言語English
ページ(範囲)189-192
ページ数4
ジャーナルNeuroscience Letters
149
2
DOI
出版ステータスPublished - 1993 1 12
外部発表はい

ASJC Scopus subject areas

  • Neuroscience(all)

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